Publications by authors named "Anthony J Amatucci"
Article Synopsis
- - Lysophosphatidic acid (LPA) and its receptor, LPAR1, are linked to fibrotic diseases like idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc), which have serious health impacts and limited treatment options.
- - Elevated LPA levels in patient samples and preclinical studies show that the enzyme autotaxin (ATX) and LPAR1 play significant roles in inflammation and fibrosis, leading to their exploration as potential drug targets.
- - The review aims to summarize current knowledge on ATX and LPAR1 signaling, describe mechanisms of new inhibitors, and discuss clinical trial findings, highlighting the potential of these inhibitors in improving treatments for fibrotic diseases.
Introduction: Gout is an inflammatory, metabolic disease associated with a high comorbidity burden including cardiovascular disease, hypertension, type 2 diabetes, hyperlipidemia, renal disease, and metabolic syndrome. Approximately 9.2 million Americans have gout, making prognosis and treatment outcome predictors highly important.
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