Publications by authors named "Anthony I Skene"
Article Synopsis
- The EPHOS-B trial aimed to evaluate the effects of perioperative anti-HER2 therapy on tumor growth and cell death in women with HER2-positive breast cancer before surgery.
- In a multicenter study involving 257 patients, various treatment groups including trastuzumab and lapatinib were tested, revealing that lapatinib led to a higher percentage of tumor response compared to trastuzumab or no treatment.
- The study found that early decreases in tumor proliferation (Ki67) are linked to better long-term outcomes, supporting a potential individualized approach to reduce treatment intensity for certain patients.
The aim of this multicenter, prospective, longitudinal phase IV study was to establish the optimal duration of neoadjuvant letrozole that would allow breast conservation surgery (BCS) in patients with early breast cancer who were initially unsuitable. Primary, invasive, estrogen-receptor- and/or progesterone-receptor-positive breast cancer patients, with large tumors (≥T2 i.e.
View Article and Find Full Text PDFPrevious studies suggest that disease recurrence peaks at around 2 years in patients with early stage breast cancer (EBC), but provide no data regarding recurrence type. This retrospective analysis aimed to identify early recurrence types and risk factors in estrogen receptor-positive (ER+) EBC patients treated with adjuvant tamoxifen following breast cancer surgery. Postmenopausal women diagnosed with ER+ EBC from 1995 to 2004 were evaluated.
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