LentiGlobin Administration to Sickle Cell Disease Patients: Effect on Serum Markers and Vaso-Occlusive Crisis.

LentiGlobin, an innovative gene therapy, introduces a modified beta-globin gene that yields an anti-sickling hemoglobin variant. It boosts total hemoglobin levels, mitigates hemolysis, curtails inflammation, and addresses iron overload by reducing transfusion requirements. These changes, in turn, provide insights into disease mechanisms and treatment outcomes.

Postpartum Ovarian Vein Thrombosis: Case Report.

Introduction: Postpartum ovarian vein thrombosis (POVT) is an uncommon diagnosis that may lead to morbidity or mortality if unrecognized.

Case Report: This report discusses a single case of POVT in a community hospital, along with the treatment and clinical course.

Conclusion: The mechanism is believed to be right-sided clot formation provoked by anatomical and hormonal changes of gestation.

Case of Orbital Compartment Syndrome Post Cardiac Arrest.

Orbital compartment syndrome (OCS) is a rare ophthalmic surgical emergency in the setting of increased intraocular pressure (IOP) Irreversible vision loss can occur without immediate surgical treatment consisting of lateral cantholysis. We present a case of acute OCS discovered after cardiopulmonary resuscitation (CPR) with subsequent immediate lateral canthotomy and notable decrease in IOP. This in part demonstrates the importance of recognizing the clinical signs of OCS with or without trauma in the emergency department in addition with preparedness to perform a vision-saving procedure.

The Diagnostic Challenge of the Pediatric Brain Abscess.

Pediatric brain abscess (PBA) is a rare condition that portends a high mortality rate if not recognized and treated early. The spectrum of clinical manifestations of this disease process is wide and can often be vague, making it difficult for timely diagnosis in the emergency department. We detail the presentation of a four-year-old male with autism and a four-day history of decreased activity after a fall with a critical and rapidly worsening clinical course.

Acute Myeloid Leukemia Complicated by Hyperleukocytosis and Leukostasis in the Emergency Department.

Acute myeloid leukemia (AML) and other hematologic malignancies can be complicated by hyperleukocytosis, which leads to an increased risk for other severe complications such as tumor lysis syndrome, disseminated intravascular coagulation (DIC), and leukostasis. In this report, we present a case of a 65-year-old female with newly diagnosed AML complicated by leukostasis. We briefly review the clinical significance as well as initial diagnostic and therapeutic considerations pertaining to hyperleukocytosis and its associated complications.

Bedside Ocular Ultrasound Diagnosis of a Traumatic Lens Dislocation.

Rapid identification of ophthalmologic emergencies can be challenging in the ED, and a missed or delayed diagnosis may have vision-threatening consequences. The application of ocular point-of-care ultrasound (POCUS) by the emergency physician (EP) can facilitate the timely recognition of a myriad of emergent eye conditions. This report describes a case in which EP-performed POCUS established the prompt diagnosis of a traumatic lens dislocation in a patient with chronic vision changes.

Recognizing Belhassen Ventricular Tachycardia and Preventing Its Misinterpretation as Supraventricular Tachycardia: An Unusual Case Report.

Belhassen ventricular tachycardia (BVT), also known as verapamil-sensitive ventricular tachycardia, is an infrequent finding that can be fatal unless recognized early and treated in a prompt manner. Most patients have insignificant presentation suggestive of the disease, but on electrocardiography (EKG), BVT is characterized by a complete right branch block (RBB) and a right axis deviation (RAD). In this case report, we describe an unusual case of a 35-year-old male patient who presented to the emergency department (ED) complaining of acute palpitations of two-hour duration; subsequent diagnostic testing revealed BVT in the patient.

Acute Appendicitis: Clinical Clues and Conundrums Related to the Greatest Misses.

Introduction In the United States (US), appendicitis is the most common acute abdominal emergency requiring surgery. Patients with appendicitis continue to display a complex and atypical range of clinical manifestations, providing a subsequent high risk for emergency physicians to miss acute abdominal pathology on a patient's initial visits. Due to the risk of potential perforation, the proper and timely clinical identification of acute appendicitis is vital.