Publications by authors named "Anthony Dumas"
J Thromb Thrombolysis
December 2024
Article Synopsis
- FXIIa is a plasma protease in the contact activation pathway, and inhibiting it could lead to safer anticoagulation treatments without the bleeding risks of current options.!*
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- The study tested an amidine-containing molecule (inhibitor 1) and found it primarily inhibits human FXIIa with an IC value of ~30 µM, while showing variable selectivity against other factors involved in blood coagulation.!*
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- Inhibitor 1 effectively prolongs clotting time in plasma without significant cytotoxicity, making it a promising candidate for further development as a safer anticoagulant for thromboembolic diseases.!*
