Phospholamban Cardiomyopathy Leading to Advanced Heart Failure in an Active Duty Service Member.

A phospholamban mutation is a rare genetic cause of dilated cardiomyopathy (DCM). Our case describes a young service member who presented with advanced heart failure and was found to have a familial DCM from an autosomal dominant phospholamban mutation. He ultimately underwent a successful heart transplant just 23 days after his initial presentation.

Synthesis of enantioenriched spirocyclic 2-arylpiperidines kinetic resolution.

Kinetic resolution of -Boc-spirocyclic 2-arylpiperidines with spiro substitution at C-4 was achieved with high enantiomeric ratios using the chiral base -BuLi/sparteine. Cyclopropanation or metallaphotoredox catalysis were used to access the piperidines, which could be further functionalised without loss of enantiopurity, highlighting their use as potential 3D fragments for drug discovery.

Electrochemical Benzylic C(sp)-H Direct Amidation.

Amide bonds are ubiquitous and found in a myriad of functional molecules. Although formed in a reliable and robust fashion, alternative amide bond disconnections provide flexibility and synthetic control. Herein we describe an electrochemical method to form the non-amide C-N bond from direct benzylic C(sp)-H amidation.

Narrative review of management of cirrhosis during the treatment of hepatocellular carcinoma.

Background And Objective: The management of hepatocellular carcinoma (HCC) and cirrhosis are closely linked. HCC most often occurs in the background of cirrhosis and can also lead to decompensation of underlying liver disease. The treatment of complications of cirrhosis is important to help reduce morbidity and mortality and allow for expanded treatment options of HCC.

Kinetic Resolution of 2-Aryldihydroquinolines Using Lithiation - Synthesis of Chiral 1,2- and 1,4-Dihydroquinolines.

Highly enantiomerically enriched dihydrohydroquinolines were prepared in two steps from quinoline. Addition of aryllithiums to quinoline with tert-butoxycarbonyl (Boc) protection gave N-Boc-2-aryl-1,2-dihydroquinolines. These were treated with n-butyllithium and electrophilic trapping occurred exclusively at C-4 of the dihydroquinoline, a result supported by DFT studies.

Photocatalysis and Kinetic Resolution by Lithiation to Give Enantioenriched 2-Arylpiperazines.

Piperazines are important heterocycles in drug compounds. We report the asymmetric synthesis of arylpiperazines by photocatalytic decarboxylative arylation (metallaphotoredox catalysis) then kinetic resolution using -BuLi/(+)-sparteine. This gave a range of piperazines with very high enantioselectivities.

Kinetic Resolution of 2-Aryl-4-methylenepiperidines toward Enantioenriched Functionalizable Piperidine Fragments.

The base -BuLi with sparteine allows a kinetic resolution of -Boc-2-aryl-4-methylenepiperidines. The 2,2-disubstituted products and recovered starting materials were isolated with high enantiomeric ratios. From VT-NMR spectroscopy and DFT studies, the rate of rotation of the -Boc group is fast.

Ultrasonic Sound Guide System with Eyeglass Device for the Visually Impaired.

The ultrasonic sound guide system presents the audio broadcasting system based on the inaudible ultrasonic sound to assist the indoor and outdoor navigation of the visually impaired. The transmitters are placed at the point of interest to propagate the frequency modulated voice signal in ultrasonic sound range. The dual channel receiver device is carried by the visually impaired person in the form of eyeglasses to receive the ultrasonic sound for the voice signal via demodulation.

Asymmetric Synthesis of 2-Arylindolines and 2,2-Disubstituted Indolines by Kinetic Resolution.

Kinetic resolution of 2-arylindolines (2,3-dihydroindoles) was achieved by treatment of their N-tert-butoxycarbonyl (Boc) derivatives with n-butyllithium and sparteine in toluene at -78 °C followed by electrophilic quench. The unreacted starting materials together with the 2,2-disubstituted products could be isolated with high enantiomer ratios. Variable temperature NMR spectroscopy showed that the rate of Boc rotation was fast (ΔG ≈57 kJ/mol at 195 K).

Single-Channel Multiple-Receiver Sound Source Localization System with Homomorphic Deconvolution and Linear Regression.

The conventional sound source localization systems require the significant complexity because of multiple synchronized analog-to-digital conversion channels as well as the scalable algorithms. This paper proposes a single-channel sound localization system for transport with multiple receivers. The individual receivers are connected by the single analog microphone network which provides the superimposed signal over simple connectivity based on asynchronized analog circuit.

Gastrointestinal Bleeding in Patients With Coronavirus Disease 2019: A Matched Case-Control Study.

Introduction: Although current literature has addressed gastrointestinal presentations including nausea, vomiting, diarrhea, abnormal liver chemistries, and hyperlipasemia as possible coronavirus disease 2019 (COVID-19) manifestations, the risk and type of gastrointestinal bleeding (GIB) in this population is not well characterized.

Methods: This is a matched case-control (1:2) study with 41 cases of GIB (31 upper and 10 lower) in patients with COVID-19 and 82 matched controls of patients with COVID-19 without GIB. The primary objective was to characterize bleeding etiologies, and our secondary aim was to discuss outcomes and therapeutic approaches.

Endoscopic Ultrasound Guided Gastroenterostomy: What Is the Learning Curve?

Introduction: Endoscopic ultrasound guided gastroenterostomy (EUS-GE) is a minimally invasive option for gastric outlet obstruction. It requires skills in endoscopic ultrasound, fluoroscopy, and lumen-apposing metal stent deployment. The aim of this study was to determine the learning curve for EUS-GE.

Parametric Estimations Based on Homomorphic Deconvolution for Time of Flight in Sound Source Localization System.

Vehicle-mounted sound source localization systems provide comprehensive information to improve driving conditions by monitoring the surroundings. The three-dimensional structure of vehicles hinders the omnidirectional sound localization system because of the long and uneven propagation. In the received signal, the flight times between microphones delivers the essential information to locate the sound source.

Vaccination in the Elderly and IBD.

Purpose Of Review: Significant gaps in knowledge and utilization of vaccinations exist among practitioners providing care for patients with IBD. This review is intended to update the reader on best practices for vaccination within the IBD population with a specific focus on the elderly.

Recent Findings: Advances in IBD therapeutics have recently increased the number of immunosuppressive therapies available to practitioners.