Pleiotropic attenuating effect of against isoprenaline-induced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na, K-ATPase activities.

Objective: Myocardial infarction (MI) is linked to an imbalance in the supply and demand of blood oxygen in the heart muscles. Beta-blockers and calcium antagonists are just two of the common medications used to treat MI. However, these have reportedly been shown to be either ineffective or to have undesirable side effects.

Finnish diabetes risk score outperformed triglyceride-glucose index in diabetes risk prediction.

Purpose: Triglyceride-Glucose (TyG) index is a surrogate marker of insulin resistance. This study compared the performance of TyG index and the Finnish diabetes risk score (FINDRISC) in diabetes risk prediction.

Methods: This cross-sectional study involved 122 young adults (aged 15-35 years) in Asaba, Delta State, Nigeria.

modulates ET-I/NO signalling in Lead Acetate induced rat model of endothelial dysfunction: Involvement of oxido-inflammatory mediators.

This study investigated the modulatory effect of extract on lead acetate-induced endothelial dysfunction. Animals were administered GBE (50 mg/kg and 100 mg/kg orally) after exposures to lead acetate (25 mg/kg orally) for 14 days. Aorta was harvested after euthanasia, the tissue was homogenised, and supernatants were decanted after centrifuging.

attenuates phenylhydrazine-induced anaemia and hepato-renal toxicity in male Wistar rat by boosting blood cells, modulation of lipoproteins and up-regulation of antioxidant armouries.

Aim: This study investigated the haematinic, antihyperlipidaemic, hepato-renal protective effects of aqueous leaf extract on male Wistar rats exposed to phenylhydrazine toxicity.

Methods: Animals were exposed to phenylhydrazine (PHZ) 50 mg/kg intraperitoneal for two consecutive days thereafter, treated with extract (100 mg/kg and 200 mg/kg) orally for 21 days. After the experimentation, animals were sedated with ketamine (70 mg/kg) and euthanized by cervical dislodgement.