Publications by authors named "Anthony A Snead"

Article Synopsis
  • Amphibians are a diverse group of tetrapods facing significant threats, with about 41% of species at risk of extinction due to various factors like habitat loss and climate change.
  • Genomic research on amphibians is critical for understanding their biology, including unique traits like tissue regeneration and adaptation, yet it has lagged behind other vertebrates due to technical challenges.
  • The newly formed Amphibian Genomics Consortium (AGC) aims to enhance global collaboration and accelerate genomic research in amphibians, with over 282 members from 41 countries already involved.
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Article Synopsis
  • * The 1000 Genomes Project and Oxford Nanopore Technologies are working together to produce LRS data from at least 800 samples to enhance the identification of genetic variations and better understand human genetic diversity.
  • * Initial analysis of 100 samples shows high accuracy in detecting genetic variants, including structural variants that disrupt gene function, and provides valuable data for the clinical genetics community to advance research on pathogenic variations.
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Drift and gene flow affect genetic diversity. Given that the strength of genetic drift increases as population size decreases, management activities have focused on increasing population size through preserving habitats to preserve genetic diversity. Few studies have empirically evaluated the impacts of drift and gene flow on genetic diversity.

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Amphibians represent a diverse group of tetrapods, marked by deep divergence times between their three systematic orders and families. Studying amphibian biology through the genomics lens increases our understanding of the features of this animal class and that of other terrestrial vertebrates. The need for amphibian genomic resources is more urgent than ever due to the increasing threats to this group.

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Article Synopsis
  • * The 1000 Genomes Project ONT Sequencing Consortium is working to generate LRS data from at least 800 samples to better understand human genetic variation and improve variant detection.
  • * Initial data from the first 100 samples show high accuracy in identifying structural variants and methylation signatures, creating a useful public resource for finding disease-related genetic changes.
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Passive dispersal via wind or ocean currents can drive asymmetric gene flow, which influences patterns of genetic variation and the capacity of populations to evolve in response to environmental change. The mangrove rivulus fish (), hereafter "rivulus," is an intertidal fish species restricted to the highly fragmented New World mangrove forests of Central America, the Caribbean, the Bahamas, and Florida. Mangrove patches are biological islands with dramatic differences in both abiotic and biotic conditions compared to adjacent habitat.

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Understanding the evolutionary consequences of anthropogenic change is imperative for estimating long-term species resilience. While contemporary genomic data can provide us with important insights into recent demographic histories, investigating past change using present genomic data alone has limitations. In comparison, temporal genomics studies, defined herein as those that incorporate time series genomic data, utilize museum collections and repeated field sampling to directly examine evolutionary change.

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Sequencing data-genomics, transcriptomics, epigenomics, proteomics, and metabolomics-have revolutionized biological research, enabling a more detailed study of processes, ranging from subcellular to evolutionary, that drive biological organization. These processes, collectively, are responsible for generating patterns of phenotypic variation and can operate over dramatically different timescales (milliseconds to billions of years). While researchers often study phenotypic variation at specific levels of biological organization to isolate processes operating at that particular scale, the varying types of sequence data, or 'omics, can also provide complementary inferences to link molecular and phenotypic variation to produce an integrated view of evolutionary biology, ranging from molecular pathways to speciation.

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