Novel wave intensity analysis of arterial pulse wave propagation accounting for peripheral reflections.

We present a novel analysis of arterial pulse wave propagation that combines traditional wave intensity analysis with identification of Windkessel pressures to account for the effect on the pressure waveform of peripheral wave reflections. Using haemodynamic data measured in vivo in the rabbit or generated numerically in models of human compliant vessels, we show that traditional wave intensity analysis identifies the timing, direction and magnitude of the predominant waves that shape aortic pressure and flow waveforms in systole, but fails to identify the effect of peripheral reflections. These reflections persist for several cardiac cycles and make up most of the pressure waveform, especially in diastole and early systole.

Modelling pulse wave propagation in the rabbit systemic circulation to assess the effects of altered nitric oxide synthesis.

Pulse wave propagation in the mature rabbit systemic circulation was simulated using the one-dimensional equations of blood flow in compliant vessels. A corrosion cast of the rabbit circulation was manufactured to obtain arterial lengths and diameters. Pulse wave speeds and inflow and outflow boundary conditions were derived from in vivo data.