Digital Twin for EEG seizure prediction using time reassigned Multisynchrosqueezing transform-based CNN-BiLSTM-Attention mechanism model.

The prediction of epileptic seizures is a classical research problem, representing one of the most challenging tasks in the analysis of brain disorders. There is active research into digital twins (DT) for various healthcare applications, as they can transform research into customized and personalized healthcare. The widespread adoption of DT technology relies on ample patient data to ensure precise monitoring and decision-making, leveraging Machine Learning (ML) and Deep Learning (DL) algorithms.

Possibility of refining carotenoid geometrical isomer analysis utilizing DFT-based quantum chemical calculations.

We performed quantum chemical calculations based on the density functional theory (DFT) for the all-E- and several Z-isomers of three commercially important carotenoids (lycopene, β-carotene, and astaxanthin) and theoretically obtained the UV-Vis spectrum, response factor (determined from absorption intensities of the all-E- and the Z-isomers), and Q-ratio for each carotenoid isomer. The calculated spectra reproduced the experimental spectral shapes (e.g.

Stabilized Astaxanthin Nanoparticles Developed Using Flash Nanoprecipitation to Improve Oral Bioavailability and Hepatoprotective Effects.

In this study, we developed stabilized astaxanthin (AX) nanoparticles (sNP/AX) to improve the physicochemical properties, oral bioavailability, and hepatoprotection of AX. A flash nanoprecipitation technique was used with a multi-inlet vortex mixer to prepare the sNP/AX. Vitamins E (VE) and C (VC) were used as co-stabilizers with poloxamer 407 as a stabilizer to inhibit the oxidative degradation of AX during sNP/AX formation and storage.

The efficacy of alpha-lipoic acid in the management of burning mouth syndrome: An updated systematic review of randomized controlled clinical trials.

Background And Aims: Burning mouth syndrome (BMS) causes burning or uncomfortable feelings in the oral cavity without any obvious injuries. This condition's etiopathogenesis is still unknown, consequently, BMS management is very challenging. Alpha-lipoic acid (ALA) is a naturally occurring potent bioactive compound that has been found to be useful in the management of BMS in many studies.

Lysophosphatidylcholine-based liposome to improve oral absorption and nephroprotective effects of astaxanthin.

Background: The present study was aimed to develop astaxanthin (AX)-loaded liposomes by the utilization of soybean phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) to improve the nutraceutical properties of AX. AX-loaded liposomes consisting of PC (PC/AX) and LPC (LPC/AX) were evaluated in terms of particle size distribution, morphology, release characteristics, pharmacokinetic behavior, and nephroprotective effects in a rat model of acute kidney injury.

Results: PC/AX and LPC/AX had uniform size distributions with a mean particle size of 254 and 148 nm, respectively.

Zinc status and coronary artery disease: A systematic review and meta-analysis.

Background: The association between serum zinc (Zn) levels and coronary artery disease (CAD) has been elucidated, but no previous meta-analysis was done to provide firm evidence. Therefore, this systematic review and meta-analysis was aimed to investigate the possible association between serum Zn levels and CAD patients.

Methods: Relevant studies were identified using various electronic databases (PubMed, Scopus, Embase, Google Scholar, and Web of Science) searching up to May 2021.

Molecular insight into arsenic uptake, transport, phytotoxicity, and defense responses in plants: a critical review.

A critical investigation into arsenic uptake and transportation, its phytotoxic effects, and defense strategies including complex signaling cascades and regulatory networks in plants. The metalloid arsenic (As) is a leading pollutant of soil and water. It easily finds its way into the food chain through plants, more precisely crops, a common diet source for humans resulting in serious health risks.

Synthesis and Application of Rare Deoxy Amino l-Sugar Analogues to Probe Glycans in Pathogenic Bacteria.

Bacterial cell envelope glycans are compelling antibiotic targets as they are critical for strain fitness and pathogenesis yet are virtually absent from human cells. However, systematic study and perturbation of bacterial glycans remains challenging due to their utilization of rare deoxy amino l-sugars, which impede traditional glycan analysis and are not readily available from natural sources. The development of chemical tools to study bacterial glycans is a crucial step toward understanding and altering these biomolecules.

The prevalence of hepatitis B virus infection in Bangladesh: a systematic review and meta-analysis.

Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection is one of the major public health problems worldwide, mostly in developing countries. This systematic review and meta-analysis were performed to estimate the pooled prevalence of HBV infection in Bangladesh. We systematically searched various electronic databases to retrieve relevant studies published until April 2021.

A potent cadmium bioaccumulating strain displays phytobeneficial property in Cd-exposed rice seedlings.

In agricultural soil, cadmium (Cd) pollution compromises soil health, reduces crop yield, and produces Cd-contaminated crops. Bio-based approaches are necessary as an eco-friendly and sustainable solution to mitigate Cd-polluted areas. A heavy metal-resistant rhizobacterial strain (AS10) has been isolated from a heavy metal-defiled rice field.

Total Synthesis of the Repeating Unit of Zwitterionic Polysaccharide Sp1.

Reported herein is the total synthesis of the trisaccharide repeating unit of zwitterionic polysaccharide Sp1 containing a rare sugar, 2-acetamido-4-amino-2,4,6-trideoxy-d-galactose (AAT), and three consecutive 1,2--glycosidic linkages. The total synthesis was completed via highly stereoselective glycosylations and late-stage oxidation as key steps involving a longest linear sequence of 21 steps with 4.4% overall yield.

The association of oxidative stress biomarkers with type 2 diabetes mellitus: A systematic review and meta-analysis.

Background And Aims: Oxidative stress plays a major role in the development of type 2 diabetes mellitus (T2DM). However, there were controversial outcomes in the literature between the association of oxidative stress biomarkers and T2DM. The purpose of this systematic review and meta-analysis was to critically examine the association of oxidative stress biomarkers with T2DM.

Charge-transfer-induced 2D ferromagnetism and realization of thermo-remnant memory effect in ultrathin-NiOOH-encapsulated graphene.

For graphene-based 2D materials, charge transfer at the interface between graphene and ferromagnetic metal leads to many intriguing phenomena. However, because of the unidirectional spin orientation in ferromagnetic transition metals, interface interaction plays a detrimental role in diminishing the magnetic parameters on 2D surfaces. To overcome this issue, we have synthesized ultrathin 2D weak antiferromagnetic-NiOOH layers on a graphene surface.

Reproductive biology of mud crabs () collected from Paikgachha, Khulna, Bangladesh.

Objective: This study was carried out to estimate the sex ratio, maturity size, gonadosomatic index (GSI), and peak breeding season of mud crabs.

Materials And Methods: Samples were collected randomly from the estuary and river of the study area. Sampling was carried out monthly from April to September at every full moon during one high tide.

Unraveling the heavy metal resistance and biocontrol potential of Pseudomonas sp. K32 strain facilitating rice seedling growth under Cd stress.

Heavy metal and metalloid toxicity in agricultural land needs special attention for crop production essential to feed increasing population globally. Plant growth-promoting rhizobacteria (PGPR) are native biological agents that have tremendous potential to augment crop production in contaminated fields. This study involves selection and identification (through 16S rRNA gene sequence and FAME analysis) of a potent Pseudomonas sp.

Abatement of arsenic-induced phytotoxic effects in rice seedlings by an arsenic-resistant Pantoea dispersa strain.

Population detonation and rapid industrialization are the major factors behind the reduction in cultivable land that affects crop production seriously. This situation is further being deteriorated due to the negative effects of abiotic stresses. Under such conditions, plant growth-promoting rhizobacteria (PGPR) are found to improve crop production which is essential for sustainable agriculture.

Prevalence of chronic kidney disease in Bangladesh: a systematic review and meta-analysis.

Background: Worldwide, chronic kidney disease (CKD) is a major public health issue, with a leading cause of death and disability. The aim of our study to estimate the prevalence of CKD in the Bangladeshi population based on existing data of previous studies.

Methods: In this systematic review and meta-analysis study, electronic search engines of PubMed, Google Scholar, Scopus, and the national journal databases were used to find relevant published articles until December 31, 2019.

Evaluation of antinociceptive, antihyperglycemic, and membrane stabilizing activities of Roxb.

This study was undertaken to examine the antinociceptive, antihyperglycemic, and membrane stabilizing activity with phytochemical screening of methanolic extract of whole plant. The extracts were subjected to antinociceptive, antihyperglycemic activity in laboratory animals and membrane stabilizing activity. In peripheral antinociceptive activity, (400 and 200 mg/kg) exhibited significant (P < 0.

Application of Euclidean distance measurement and principal component analysis for gene identification.

Gene systems are extremely complex, heterogeneous, and noisy in nature. Many statistical tools which are used to extract relevant feature from genes provide fuzzy and ambiguous information. High-dimensional gene expression database available in public domain usually contains thousands of genes.

Ripening of fleshy fruit: molecular insight and the role of ethylene.

Development and ripening in fruit is a unique phase in the life cycle of higher plants which encompasses several stages progressively such as fruit development, its maturation, ripening and finally senescence. During ripening phase, several physiological and biochemical changes take place through differential expression of various genes that are developmentally regulated. Expression and/or suppression of these genes contribute to various changes in the fruit that make it visually attractive and edible.