Prognostic Relevance of Circulating 25OHD Fractions for Early Recovery and Survival in Patients with Hip Fracture .

Unlabelled: The relation between vitamin-D (VD) status and healing after hip fracture had not been sufficiently addressed. Currently serum total 25-hydroxy-VD (t-25OHD) is the most widely used indicator of VD status. It is unclear whether free or bioavailable VD are better markers of 25OHD availability for tissues.

[Vitamin D and calcium supplementation in elderly patients with hip fracture].

Vitamin D plays an important role in maintaining calcium and bone metabolism, a risk factor of osteoporosis, fall and fracture in old age. Reduction in D-vitamin levels associated with compensatory increased level of parathyroid hormone causes significant loss of bone matrix, so substitutions of vitamin D and calcium are very important. Many authors publish their recommended doses used for prevention of hip fracture during the last years.

[Vitamin D supply of patients with hip fracture].

Introduction: Vitamin D deficiency is an important risk factor for fractures. However, there are few data available only on the relationship between serum 25-hydroxyvitamin D levels and recovery after surgery for hip fracture.

Aim: The authors investigate the vitamin D supply of patients with hip fractures.

[The role of vitamin D deficiency in the pathogenesis of falls and fractures].

The diverse effects of vitamin D in human body became known during the last years. Vitamin D deficiency causes many problems in medical care. Important roles of vitamin D are the regulation of calcium metabolism and the effect on bone metabolism.

[The role of adult bone marrow derived mesenchymal stem cells in the repair of tissue injuries].

Mesenchymal stem cells, which reside in adult bone marrow are multipotent, have an excellent regeneration potential for tissue repair. These cells are able to differentiate in cell culture not only into mesodermal lineages but also into other lineages of ectodermal and endodermal cells. This regenerative process is assisted by application of bioactive molecules, specific growth factors and biomaterials (scaffolds).

[Use of mesenchymal stem cells from adult bone marrow for injured tissue repair].

Mesenchymal stem cells are known as being multipotent and exhibit the potential for differentiation into different cells/tissue lineages, including cartilage, bone, adipose tissue, tendon, and ligament. These pluripotent mesenchymal progenitor cells are denoted as stromal or mesenchymal stem cells. Bone marrow contains two main cell types: hematopoietic cells and stromal cells.

The role of adult bone marrow derived mesenchymal stem cells, growth factors and carriers in the treatment of cartilage and bone defects.

Human mesenchymal stem cells, which reside in adult bone marrow, have an excellent regeneration potential for tissue repair. These cells can expand in culture into lineages of mesenchymal tissues and they are able to differentiate into cartilage, bone and other tissues. This regenerative process is assisted by application of bioactive molecules, specific growth factors, signaling molecules and biomaterials (scaffolds).

[Role of fibroblasts in physiologic, reparative and pathologic processes].

Fibroblast is counted as one of the important cell of the connective tissue. At the present time many phenotypes are known taking part in normal, repair and pathological processes, meanwhile cellular and molecular events occur, where fibroblasts play essential role. Among molecular factors, first of all integrins, growth factors, cytokines and matrix molecules are discussed.