Gestational administration of aqueous leaf extract of Jatropha tanjorensis alleviated postpartum emotional and cognitive dysfunction in rats (Wistar strain).

This study examines the effect of gestational administration of aqueous leaf extract of Jatropha tanjorensis (JT) on postpartum-like behavioural outcomes to delineate its possibility as a prophylactic, therapeutic agent in the treatment of postpartum symptoms. Inseminated female rats (120-150g) were grouped into two-control and JT group (n=10). Control received 20 ml/kg of distilled water and JT group received 500 mg/kg of JT orally once daily for 21 days in gestation.

Consumption of Aqueous Leaf Extract of Jatropha tanjorensis Improves Fertility Potential and Gestational Outcome in Virgin Female Wistar Rats.

In spite of the overwhelming patronage of the plant Jatropha tanjorensis (J.T) popularly called "Hospital Too Far" by pregnant and women of reproductive age for its supposed reproductive benefits, the scientific evidence are hardly known. This study thus sought to examine the effect of consumption of aqueous leaf of J.

Production, characterization and techno-economic evaluation of Aspergillus fusant L-asparaginase.

Protoplast fusion is one of the most reliable methods of introducing desirable traits into industrially-promising fungal strains. It harnesses the entire genomic repertoire of fusing microorganisms by routing the natural barrier and genetic incompatibility between them. In the present study, the axenic culture of a thermo-halotolerant strain of Aspergillus candidus (Asp-C) produced an anti-leukemic L-asparaginase (L-ASNase) while a xylan-degrading strain of Aspergillus sydowii (Asp-S) produced the acrylamide-reduction type.

Interspecific protoplast fusion of atmospheric and room-temperature plasma mutants of generates an L-asparaginase hyper-producing hybrid with techno-economic benefits.

The axenic culture of (Asp-C) produced an anti-leukemic L-asparaginase while (Asp-S) produced the acrylamide-reduction type. Upon mutagenesis by atmospheric and room-temperature plasma (ARTP), their individual L-asparaginase activities improved 2.3-folds in each of IleThrAsp-C-180-K and ValAsp-S-180-E stable mutants.

A novel strain of Stenotrophomonas acidaminiphila produces thermostable alkaline peptidase on agro-industrial wastes: process optimization, kinetic modeling and scale-up.

Bacterial alkaline peptidases, especially from Bacillus species, occupy the frontline in global enzyme market, albeit with poor production economics. Here, we report the deployment of response surface methodology approximations to optimize fermentation parameters for enhanced yield of alkaline peptidase by the non-Bacillus bacterium; Stenotrophomonas acidaminiphila. Shake flask production under optimized conditions was scaled up in a 5-L bench-scale bioreactor.

Overproduction of a thermo-stable halo-alkaline protease on agro-waste-based optimized medium through alternate combinatorial random mutagenesis of .

A strain of , isolated from fermenting bean-processing wastewater, produced alkaline protease in pretreated cassava waste-stream, but with low yield. Strain improvement by alternate combinatorial random mutagenesis and bioprocess optimization using comparative statistical and neural network methods enhanced yield by 17.8-fold in mutant kGy-04-UV-25.

Refractory Methamphetamine-Induced Psychosis: An Emerging Crisis in Rural America and the Role of Amantadine in Therapeutics.

In the last decade, methamphetamine (MA) use has substantially increased in rural America. These changes in the epidemiological trends could be attributed to the restricted availability of opioids after measures against the opioid epidemic were enforced. The availability of cheaper alternatives, such as fake prescriptions mixed with fentanyl, is a few among the many recent developments in the ongoing mental health and substance abuse crisis in rural America.

Kinetic modeling and quasi-economic analysis of fermentative glycolipopeptide biosurfactant production in a medium co-optimized by statistical and neural network approaches.

This study presents the kinetics of production of a glycolipopeptide biosurfactant in a medium previously co-optimized by response surface and neural network methods to gain some insight into its volumetric and specific productivities for possible scale-up towards industrial production. Significant kinetic parameters including maximum specific growth rate, µmax, specific substrate consumption rate, qs and specific biosurfactant yield, Yp/x were determined from logistic model parameters after comparison with other kinetic models. Results showed that bio-catalytic rates of lipase and urease reached exponential values within the first 12 h of fermentation leading to high specific rates of substrate consumption and bacterial growth.

Iron Status of Pregnant Women in Rural and Urban Communities of Cross River State, South-South Nigeria.

Anaemia in pregnancy is a major public health problem in Nigeria. Iron deficiency is one of the major causes of anaemia in pregnancy.  Inadequate iron intake during pregnancy can be dangerous to both baby and mother.

Effect of lemongrass tea consumption on estimated glomerular filtration rate and creatinine clearance rate.

Objectives: The existing research findings regarding the effects of lemongrass (Cymbopogon citratus) tea on renal function indices are conflicting and inconclusive. In the present study, we investigated the effects of infusions prepared from C citratus leaves on creatinine clearance rate (CCr) and estimated glomerular filtration rate (eGFR) in humans.

Design And Methods: One hundred five subjects (55 men and 50 women) aged 18 to 35 years were randomly assigned to groups set to orally receive infusions prepared from 2, 4, or 8 g of C citratus leaf powder once daily, for 30 days.

Bioactive natural constituents from lemongrass tea and erythropoiesis boosting effects: potential use in prevention and treatment of anemia.

This study assessed the effects of lemongrass (Cymbopogon citratus) tea on hematologic indices in human volunteers. One hundred five subjects (55 men and 50 women), aged 18 to 35 years, were randomly assigned to groups set to orally receive infusion prepared from 2, 4, or 8 g of C. citratus leaves once daily for 30 days.

Altered biliary flow rate and bile composition following consumption of ethanolic fruit extract of Dennettia in rats.

Background: Dennettia tripetala is a tropical plant with some ethno-medicinal uses; it enhances uterine contraction/involution in pregnant and post-partum women, it is also a mild laxative, with anti-bacteria, antifungal properties etc..

Aims: This study sought to elucidate the impact of D.

Chronic consumption of three forms of palm oil diets alters glomerular filtration rate and renal plasma flow.

The effects of chronic consumption of three types of palm oil diets on glomerular filtration rate (GFR), renal plasma flow (RPF) and blood pressure were studied. Wistar rats were randomly assigned into four groups of ten rats each, respectively: control, fresh (FPO), photoxidized (PPO), thermoxidized (TPO) palm oil diet-fed rats. The control group was fed rat chow only, while experimental groups had different palm oil diets at 15% wt/wt for twelve weeks and tap water ad libitum.

Gastric acid anti-secretory, anti-ulcerogenic and mucogenic effects of aqueous leaves' extract of Ocimum gratissimum in rats.

In this study, albino Wistar rats were placed on normal rats chow + drinking water and/or 500mg/kg, 1000mg/kg body weight of the Ocimum gratissimum extract orally, once daily for 28 days and gastric acid, mucus and ulcers determined. All the rats received normal rat chow + drinking water ad libitum for 28 days. Gastric acid, mucus secretion and ulcer scores were determined with standard procedures.

Intestinal Fluid and Glucose Transport in Wistar Rats following Chronic Consumption of Fresh or Oxidised Palm Oil Diet.

Chronic ingestion of thermoxidized palm oil causes functional derangement of various tissues. This study was therefore carried out to determine the effect of chronic ingestion of thermoxidized and fresh palm oil diets on intestinal fluid and glucose absorption in rats using the everted sac technique. Thirty Wistar rats were divided into three groups of 10 rats per group.

Serum protein and enzyme levels in rats following administration of ethanolic leaf extract of Ageratum conyzoides (goat weed).

The The potential hepatotoxic effects following oral administration of ethanolic leaf extract of Ageratum conyzoides (goat weed) was investigated in albino Wistar rats. Twenty eight (28) adult male Wistar rats were uniformly divided into four groups of seven rats each. Group 1 served as control while groups 2, 3 and 4 were respectively gavaged with 200 mg/kg body weight, 400 mg/kg body weight and 600 mg/kg body weight of the extract daily for 21 days.

Phytochemistry and some haematological changes following oral administration of ethanolic root extract of Gongronema latifolium in rats.

Gongronema latifolium is a climbing perennial plant that belongs to the family of asclepidaceae. The medicinal uses of the leaves and stem bark extract of Gongronema latifolium has been reported in many scientific literatures to include anti-hyperglycaemic, anti-ulcerative etc. There is paucity in scientific reports on the medicinal properties of the root extract.

Viscum album (mistletoe) extract prevents changes in levels of red blood cells, PCV, Hb, serum proteins and ESR in high salt-fed rats.

Aim Of The Study: The present study was aimed to determine the effects of Viscum album (mistletoe) on red blood cells, packed cell volume, Hb content, absolute haematological values {mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), colour index (CI)}, plasma proteins and ESR in high salt-fed rats.

Materials And Methods: 24 male albino Wistar rats were divided into 4 groups of 6 rats each. Group 1 received normal rat pellets+drinking water.

Intestinal motility and transit following chronic ingestion of different forms of palm oil diets.

This study was aimed at finding the effect of palm oil diets on the small intestinal motor activity and transit in rats. Adult albino Wistar rats were divided into three groups of ten rats each. The first group was fed on rat chow containing 15% (wt/wt) of fresh palm oil diets for fifteen weeks.

Effect of multiparity on electrolyte composition and blood pressure.

Pregnancy affects the physiology of the pregnant woman particularly the endocrine, cardiovascular and the renal systems. This work was therefore set to ascertain the state of electrolytes in pregnancy and how it affects blood pressure using multiparity as a factor. One hundred and twenty (120) women were used in this study.

The relative incidence of diabetes mellitus in ABO/Rhesus blood groups in South-Eastern Nigeria.

A total of 224 diabetics and 221 non-diabetics (control) were involved in this study, to determine the relative incidence of diabetes mellitus in ABO/Rhesus blood group. The current criteria for the diagnosis of diabetes mellitus were applied in differentiating the diabetics from the non-diabetics. Blood group, fasting blood sugar (FBS) and random blood sugar (RBG) were determined using standard methods.

Stimulation of gastric acid secretion and intestinal motility by Vernonia amygdalina extract.

Aqueous extract of Vernonia amygdalina infused intragastrically at a dose of 10 mg/ml to rats induced a significant increase in acid output which was reduced by, ranitidine (5 mg/kg b.w.) or atropine (1.

Vitamin C improves basal metabolic rate and lipid profile in alloxan-induced diabetes mellitus in rats.

Diabetes mellitus (DM)is a multi-factorial disease which is characterized by hyperglycaemia, lipoprotein abnormalities and oxidative stress. This study evaluated effect of oral vitamin C administration on basal metabolic rate and lipid profile of alloxan-induced diabetic rats. Vitamin C was administered at 200 mg/kg body wt.

Preliminary studies on effect of chloroquine phosphate on gastric acid secretion in rats.

It is not certain whether chloroquine-induced pruritus is mainly attributable to the liberation of histamine, a powerful gastric acid secretagogue from mast cells, which may not be beneficial in peptic ulceration. Therefore, the aim of this study was to find out whether chloroquine (CQ) can stimulate gastric acid secretion in the rat. Gastric acid output was measured by the continuous perfusion of rats stomachs under anaesthesia with normal saline at the rate of 1ml per minutes.