Publications by authors named "Anshuman Jaysingh"
Article Synopsis
- Actin polymerization is regulated by proteins with capping-protein-interacting (CPI) motifs that affect the binding of capping proteins, which normally inhibit actin filament growth.
- The protein V-1/myotrophin binds to capping proteins, hindering their ability to cap the growing ends of actin filaments.
- Experiments showed that CARMIL, when present on a membrane-like surface, enhances actin assembly by counteracting V-1's inhibitory effects and activating capping proteins.
Actin polymerization is often associated with membrane proteins containing capping-protein-interacting (CPI) motifs, such as CARMIL, CD2AP, and WASHCAP/Fam21. CPI motifs bind directly to actin capping protein (CP), and this interaction weakens the binding of CP to barbed ends of actin filaments, lessening the ability of CP to functionally cap those ends. The protein V-1 / myotrophin binds to the F-actin binding site on CP and sterically blocks CP from binding barbed ends.
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