Comprehensive profiling of rRNA-derived small RNAs in using rsRNAfinder pipeline.

Ribosomal RNA (rRNA) gives rise to non-random small RNA fragments known as ribosomal-derived small RNAs (rsRNAs), which despite their biological importance, have been relatively understudied in comparison to other short non-coding RNAs. There exists a compelling necessity to develop a methodology for the identification, categorization, and quantification of rsRNAs from small RNA sequencing (sRNA-seq) data sets, considering the unique characteristics of ribosomal RNA (rRNA). To bridge this gap, we introduce 'rsRNAfinder' a specialized pipeline designed within the Snakemake framework.

Potential inhibitors of SARS-CoV-2 (COVID 19) proteases PL and M/ 3CL: molecular docking and simulation studies of three pertinent medicinal plant natural components.

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - coronavirus disease 2019 (COVID-19) has raised a severe global public health issue and creates a pandemic situation. The present work aims to study the molecular -docking and dynamic of three pertinent medicinal plants , and phyto-compounds against SARS-COV-2 papain-like protease (PL) and main protease (M)/3-chymotrypsin-like protease (3CL). The interaction of protein targets and ligands was performed through AutoDock-Vina visualized using PyMOL and BIOVIA-Discovery Studio 2020.

Molecular docking and simulation studies of natural compounds of L. against papain-like protease (PL) of SARS CoV-2 (coronavirus) to conquer the pandemic situation in the world.

The severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is β-coronavirus that is responsible for the pandemic coronavirus disease 2019 (COVID-19) all over the world. The rapid spread of the novel SARS CoV-2 worldwide is raising a significant global public health issue with nearly 61.86 million people infected and 1.