Publications by authors named "Anshul B Kundaje"
Article Synopsis
- A new approach to genomics experiments involves doing fewer experiments and using computational methods to fill in the gaps, but there are still uncertainties about which imputation methods work best and how to evaluate their performance effectively.* -
- The study reviews 23 different methods from the ENCODE Imputation Challenge and discovers that assessing these methods is complicated by factors like changes in data collection practices, varying amounts of data, and overlapping evaluation metrics.* -
- The authors suggest practical solutions to these challenges and highlight promising areas for future research to improve the robustness of imputation methods in genomics.*
Article Synopsis
- A study used ChIP-Seq to explore the role of the transcription factor TCF21 in human coronary artery smooth muscle cells (HCASMC) and its connection to coronary artery disease (CAD).
- Researchers discovered that TCF21 target genes are involved in processes like growth factor binding and smooth muscle contraction, linking them to CAD mechanisms.
- The findings suggest that TCF21 interacts with genes from other disease loci, indicating its potential impact on disease risk and revealing its relevance in various biological functions beyond just vascular health.
Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that spread more broadly over genes in a given cell type preferentially mark genes that are essential for the identity and function of that cell type. Using the broadest H3K4me3 domains as a discovery tool in neural progenitor cells, we identify novel regulators of these cells.
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