Precisely tunable continuous-wave terahertz source with interferometric frequency control.

We realized a tunable continuous-wave terahertz source with megahertz frequency resolution. The system is based on optical heterodyning of two near-infrared distributed feedback diode lasers, each laser being stabilized by electronic feedback from a low-finesse quadrature interferometer. The control loop permits precisely linear laser frequency scans over >1200 GHz, and a beat signal linewidth of 1 MHz at 80 ms time scale.

3He MRI-based assessment of posture-dependent regional ventilation gradients in rats.

A recently developed method for quantitative assessment of regional lung ventilation was employed for the study of posture-dependent ventilation differences in rats. The measurement employed hyperpolarized (3)He MRI to detect the build-up of the signal intensity after increasing numbers of (3)He breaths, which allowed for computation of a regional ventilation parameter. A group of six anesthetized rats was studied in both supine and prone postures.

Quantitative measurement of regional lung ventilation using 3He MRI.

A new strategy for a quantitative measurement of regional pulmonary ventilation using hyperpolarized helium-3 (3He) MRI has been developed. The method employs the build-up of the signal intensity after a variable number of (3)He breaths. A mathematical model of the signal dynamics is presented, from which the local ventilation, defined as the fraction of gas exchanged per breath within a given volume, is calculated.