Publications by authors named "Anse Vellappally"
Article Synopsis
- This study investigates the microstructure of the lamina cribrosa (LC) in nonhuman primates with glaucoma, focusing on how it differs in those with naturally occurring disease compared to controls.
- Researchers used advanced imaging (OCT scans) to analyze the optic nerve head and select specific eyes based on retinal nerve fiber layer thickness (RNFL-T).
- Key findings show that glaucoma-affected eyes had thinner RNFL-T and smaller pore diameters in the LC, indicating potential structural changes associated with the disease.
Purpose: Lamina cribrosa (LC) deformation is hypothesized to play a major role in glaucoma pathogenesis. The purpose of this study was to determine in vivo how varying intraocular pressure (IOP) under fixed intracranial pressure (ICP), and vice versa, deforms the pore paths throughout the LC volume.
Methods: Spectral-domain optical coherence tomography scans of the optic nerve head were acquired from healthy adult rhesus monkeys under different pressures.