Free testosterone, luteinizing hormone/follicle stimulating hormone ratio and pelvic sonography in relation to skin manifestations in patients with polycystic ovary syndrome.

Objective: To evaluate hormonal changes and pelvic sonography in polycystic ovary syndrome (PCOS) patients, especially free testosterone and their correlations with skin manifestations of this disease.

Methods: This prospective study was carried out in the Skin Clinic, Baghdad Teaching Hospital, Iraq in the period between April 2004-March 2005. We included 126 patients with PCOS in this study.

Testosterone 17beta-N,N-dimethylglycinate hydrochloride: A prodrug with a potential for nasal delivery of testosterone.

The purpose of this study was to examine the potential of the nasal route for the systemic delivery of the poorly water-soluble drug testosterone (TS) using a water-soluble prodrug, TS 17beta-N,N-dimethylglycinate hydrochloride. The physicochemical properties of the prodrug, in vitro hydrolysis in human liver homogenate, and in vivo nasal and intravenous experiments were performed in rats. The aqueous solubility of the prodrug was more than 100 mg/mL, compared with 0.