Publications by authors named "Anru Yang"
Article Synopsis
- The study highlights how the DNA damage response (DDR) and blood-tumor barrier (BTB) hinder chemotherapy effectiveness in glioblastomas, resulting in frequent relapses.
- It reveals that the interplay between glioblastoma cells and myeloid cells activates GP130 receptor signaling, causing resistance to the chemotherapy drug temozolomide (TMZ) at both genetic and vascular levels.
- The research suggests that blocking GP130 can reduce DDR activity and BTB formation, potentially enhancing the effectiveness of chemotherapy for GBMs with the identification of predictive markers.
