Publications by authors named "Anran Wang"

Background: The multicohort, open-label, phase 1b KEYNOTE-173 study was conducted to investigate pembrolizumab plus chemotherapy as neoadjuvant therapy for triple-negative breast cancer (TNBC). This exploratory analysis evaluated features of the tumor microenvironment that might be predictive of response.

Methods: Cell fractions from 20 paired samples collected at baseline and after one cycle of neoadjuvant pembrolizumab prior to chemotherapy initiation were analyzed by spatial localization (tumor compartment, stromal compartment, or sum of tumor and stromal compartments [total tumor]) using three six-plex immunohistochemistry panels with T-cell, myeloid cell, and natural killer cell components.

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Out-of-hospital cardiac arrest is a time-sensitive emergency that requires prompt identification and intervention: sudden, unwitnessed cardiac arrest is nearly unsurvivable. A cardinal sign of cardiac arrest is sudden loss of pulse. Automated biosensor detection of unwitnessed cardiac arrest, and dispatch of medical assistance, may improve survivability given the significant prognostic role of time, but only if the false positive burden on public emergency medical systems is minimized.

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Article Synopsis
  • Acute large vessel occlusion (LVO) stroke is common and serious, with many patients facing complications despite treatment, highlighting the need to understand thrombus formation.
  • The study analyzed insoluble proteins from thrombi in patients with different stroke types (cardiogenic embolic vs. large artery atherosclerotic) using advanced mass spectrometry techniques to explore their characteristics and identify potential biomarkers.
  • Results revealed a detailed protein atlas, showing significant differences in inflammatory and extracellular matrix pathways between thrombus sources, and identified two biomarkers (IDH2 and HSPG2) that may help diagnose these conditions effectively.
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Two-dimensional (2D) transition metal dichalcogenides (TMDs), such as molybdenum disulfide (MoS), hold great promise for next-generation nanoelectronic and nanophotonic devices. While high photoresponsivity and broad spectral coverage (UV-IR) have been reported, the slow response time of MoS photodetectors caused by their unfavorable RC characteristics is still a major limit in current devices. Once the RC limit issue is resolved, the intrinsic saturation drift velocity of electrons in TMDs (∼10 cm s) may enable GHz opto-electronic operations.

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Background: Named entity recognition (NER) models are essential for extracting structured information from unstructured medical texts by identifying entities such as diseases, treatments, and conditions, enhancing clinical decision-making and research. Innovations in machine learning, particularly those involving Bidirectional Encoder Representations From Transformers (BERT)-based deep learning and large language models, have significantly advanced NER capabilities. However, their performance varies across medical datasets due to the complexity and diversity of medical terminology.

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Background: Data element repositories facilitate high-quality medical data sharing by standardizing data and enhancing semantic interoperability. However, the application of repositories is confined to specific projects and institutions.

Objective: This study aims to explore potential issues and promote broader application of data element repositories within the medical field by evaluating and analyzing typical repositories.

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Introduction: This study aimed to evaluate the efficiency of tea polyphenols (TP) and medicinal plant mixtures ( + , Bail + + ) combined with astaxanthin (AST), benzoic acid (BA), and yeast complex on the health status of .

Method: A total of 630 crabs (male crabs: 41.51 ± 1.

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Article Synopsis
  • The study explores how public flue exhaust systems in high-rise buildings affect air quality and living conditions, identifying gaps in previous research regarding the impact of individual system components.
  • It analyzes critical elements like branch pipes and check valves using computational fluid dynamics (CFD) and experiments, leading to the development of a simulation software in C# to predict flow changes.
  • The software effectively visualizes and evaluates flue performance under various building configurations, aiding in the optimal design to enhance air quality in residential areas.
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Background: Abnormal endometrial blood flow causes a decrease in endometrial receptivity and is considered a relatively independent risk factor for recurrent implantation failure (RIF). This study aimed to explore the potentially functional circRNA-miRNA-mRNA network in RIF, and further explore its mechanism.

Methods: Datasets were downloaded from the GEO database to identify differentially expressed circRNAs, miRNAs and mRNAs.

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Van der Waals heterostructures based on transition metal dichalcogenides (TMDs) have emerged as excellent candidates for next-generation optoelectronics and valleytronics, due to their fascinating physical properties. The understanding and active control of the relaxation dynamics of heterostructures play a crucial role in device design and optimization. Here, we investigate the back-gate modulation of exciton dynamics in a WS/WSe heterostructure by combining time-resolved photoluminescence (TRPL) and transient absorption spectroscopy (TAS) at cryogenic temperatures.

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This study aimed to elucidate the effects of dietary fermented products of Bacillus velezensis T23 on the growth, immune response and gut microbiota in Pacific white shrimp (Litopenaeus vannamei). Shrimp were fed with diets containing fermentation products of B. velezensis T23 at levels of (0, 0.

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FOXA1 (Forkhead Box A1) and FOXA2 (Forkhead Box A2) serve as pioneering transcription factors that build gene expression capacity and play a central role in biological processes, including organogenesis and differentiation, glycolipid metabolism, proliferation, migration and invasion, and drug resistance. Notably, FOXA1 and FOXA2 may exert antagonistic, synergistic, or complementary effects in the aforementioned biological processes. This article focuses on the molecular mechanisms and clinical relevance of FOXA1 and FOXA2 in steroid hormone-induced malignancies and highlights potential strategies for targeting FOXA1 and FOXA2 for cancer therapy.

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PbS quantum dot (QD) solar cells harvest near-infrared solar radiation. Their conventional hole transport layer has limited hole collection efficiency due to energy level mismatch and poor film quality. Here, how to resolve these two issues by using Ag-doped PbS QDs are demonstrated.

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Article Synopsis
  • Human adenovirus is being studied as a potential cancer treatment and the E4 gene's role in this therapy is being investigated.
  • The E4 proteins, particularly E4 orf4 and E4 orf6/7, have been found to inhibit NF-κB activation, which is crucial for immune responses and cancer progression.
  • The findings suggest that these E4 proteins might not only suppress NF-κB but could also enhance the anticancer effects of the adenovirus by regulating E1A expression during the later stages of infection.
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van der Waals heterostructures based on transition metal dichalcogenides (TMDs) provide a fascinating platform for exploring new physical phenomena and novel optoelectronic functionalities. Revealing the energy-dependence of photocarrier population dynamics in heterostructures is key for developing optoelectronic or valleytronic devices. Here, the broadband transient dynamics of interlayer excitation of a nearly-aligned WS/WSe heterostructure is investigated by using energy-dependent pump-probe spectroscopy at cryogenic temperatures.

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Background: Systemic therapies have improved the management of hepatocellular carcinoma, but there is still a need to further enhance overall survival in first-line advanced stages. This study aimed to evaluate the addition of pembrolizumab to lenvatinib versus lenvatinib plus placebo in the first-line setting for unresectable hepatocellular carcinoma.

Methods: In this global, randomised, double-blind, phase 3 study (LEAP-002), patients aged 18 years or older with unresectable hepatocellular carcinoma, Child Pugh class A liver disease, an Eastern Cooperative Oncology Group performance status of 0 or 1, and no previous systemic treatment were enrolled at 172 global sites.

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Background: Glucose repression in yeast leads to the sequential or diauxic utilization of mixed sugars and reduces the co-utilization of glucose and xylose from lignocellulosic biomasses. Study of the glucose sensing pathway helps to construct glucose repression-released yeast strains and enhance the utilization of lignocellulosic biomasses.

Results: Herein, the glucose sensor/receptor repressor (SRR) pathway of Kluyveromyces marxianus which mainly consisted of KmSnf3, KmGrr1, KmMth1, and KmRgt1 was studied.

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Background: We aimed to assess the prevalence of prior anticoagulation therapy (warfarin or non-vitamin K antagonist oral anticoagulants [NOACs]) among patients with acute ischemic stroke (AIS) and atrial fibrillation (AF) in China and investigate the associations between prior anticoagulation therapy and initial stroke severity and in-hospital outcomes.

Methods: We included consecutive patients with AIS and known history of AF admitted to hospitals in the China Stroke Center Alliance (CSCA) program from January 2019 to July 2019. Multivariate logistic regression analyses were performed to determine the associations between prior anticoagulation therapy and initial stroke severity and in-hospital outcomes.

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Background: Imaging indicators of early neurological deterioration (END) in patients with acute isolated pontine infarctions (AIPI) remained ambiguous. We aimed to find more specific neuroimaging markers for the development of END in patients with AIPI.

Methods: Patients with AIPI within 72 h of stroke onset were screened from a stroke database from January 2018 to July 2021 in the First Affiliated Hospital of Zhengzhou University.

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The miscibility between active layer donors (D) and acceptors (A) is a key factor impeding the development of organic photovoltaics (OPVs) toward higher performance and large-area production. In this study, melt blending crystallization (MBC) was used to accomplish molecular-level blending and highly oriented crystallization in bulk heterojunction (BHJ) films realized by a scalable blade coating process, which increased the D/A contact area and provided sufficient exciton diffusion and dissociation. At the same time, the highly organized and balanced crystalline nanodomain structures permitted dissociated carriers to be efficiently transmitted and collected, resulting in significantly enhanced short-circuit current density, fill factor, and efficiency of the device by means of optimum melting temperature and quenching rates.

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Background: Millions of catheters for invasive arterial pressure monitoring are placed annually in intensive care units, emergency rooms, and operating rooms to guide medical treatment decision-making. Accurate assessment of arterial blood pressure requires an IV pole-attached pressure transducer placed at the same height as a reference point on the patient's body, typically, the heart. Every time a patient moves, or the bed is adjusted, a nurse or physician must adjust the height of the pressure transducer.

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Effects of dietary niacin on the growth performance, intestinal histomorphology, body composition, and antioxidant capacity were investigated in the present study to determine the optimum requirement of niacin for juvenile . All 360 crabs (initial average weight 1.14 ± 0.

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Introduction: Dietary tryptophan (Trp) has been shown to influence fish feed intake, growth, immunity and inflammatory responses. The purpose of this study was to investigate the effect and mechanism of Trp on immune system of juvenile northern snakehead ( Cantor, 1842).

Methods: A total of 540 fish (10.

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Article Synopsis
  • The phase II KEYNOTE-086 study assessed the effectiveness of pembrolizumab monotherapy in treating metastatic triple-negative breast cancer (mTNBC) in two patient cohorts, focusing on biomarker associations with clinical outcomes.
  • Two cohorts were analyzed: Cohort A had patients with progressing mTNBC post-treatment, while Cohort B included treatment-naive PD-L1-positive patients; various molecular biomarkers were evaluated for their relationship with objective response rate, progression-free survival, and overall survival.
  • Significant associations were found between several biomarkers (including PD-L1, CD8, TMB, and TcellGEP) and treatment outcomes, indicating their potential as predictive indicators of response to pembrolizumab therapy.
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