Publications by authors named "Anower Jabed"
Article Synopsis
- Norovirus is the main cause of viral gastroenteritis worldwide, mainly spreading through person-to-person contact and contaminated food, especially shellfish.
- This study aims to assess norovirus infectivity in shellfish using reverse transcription quantitative PCR (RT-qPCR) and a specific dye (PMAxx-RT-qPCR) to analyze viral integrity after high-pressure processing (HPP).
- Results showed increasing non-infectious virus ratios with higher pressure and temperature conditions, indicating that high-pressure treatments can reduce the integrity and infectivity of norovirus in shellfish.
Under normal conditions, dopamine (DA) clearance after release largely depends on uptake by the DA transporter (DAT). DAT expression/activity is reduced in some neuropsychiatric and neurological disorders. Our aim was to characterize the behavioral, neurochemical and electrophysiological effects of eliminating DAT in a novel knockout rat model we generated using CRISPR/Cas9.
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- The PI3K pathway is identified as a potential target for melanoma therapy, showcasing significant genetic diversity among the early passage cell lines derived from metastatic melanomas.
- A majority of these cell lines exhibited upregulation of the PI3K pathway through various mechanisms, including genetic alterations in key PI3K components like PIK3CA and regulatory subunits.
- Inhibitors targeting the PI3K pathway showed variable effectiveness, with mTOR-selective or dual inhibitors proving to be effective against all tested lines, including those resistant to other treatments.
Article Synopsis
- Melanoma has a high mutation burden, which leads to diverse mechanisms that help it resist treatments and evade the immune system.
- Researchers characterized 102 cell lines from metastatic melanomas, analyzing genetic mutations and gene expression through whole-exome and RNA sequencing.
- The study identified various melanoma genotypes, four key subgroups based on gene expression, and specific immune-related features, making these cell lines a valuable resource for studying melanoma's biology and treatment responses.
Prostate cancer is an important health burden to the healthcare system of any country. However, with the current prostate-specific antigen biomarker having low predictive value even for diagnostic purposes, the challenge is still open to tackle this chronic disease. There have been a number of studies which have indicated and encouraged a multi-directional approach to combat this disease.
View Article and Find Full Text PDFProstate cancer is one of the most significant male health concerns worldwide, and various researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the overall risk and prognosis of this disease. Single nucleotide polymorphisms are increasingly becoming strong biomarker candidates to identify the susceptibility of individuals to prostate cancer. We carried out risk association of different stages of prostate cancer to a number of single nucleotide polymorphisms to identify the susceptible alleles in a New Zealand population and checked the interaction with environmental factors as well.
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- * A study analyzed SNPs from various European populations to pinpoint risk factors for aggressive prostate cancer, then examined interactions between these SNPs in a New Zealand group using PLINK software.
- * The findings revealed two specific intronic SNPs that significantly interacted as risk factors for aggressive prostate cancer when compared to healthy controls in New Zealand.
Prostate cancer is one of the most significant health concerns for men worldwide. Numerous researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the overall risk and prognosis of this disease. Single nucleotide polymorphisms (SNPs) are increasingly becoming strong biomarker candidates to identify susceptibility to prostate cancer.
View Article and Find Full Text PDFAge is often considered an important non-modifiable risk factor for a number of diseases, including prostate cancer. Some prominent risk factors of prostate cancer include familial history, ethnicity and age. In this review, various genetic and physiological characteristics affected due to advancing age will be analysed and correlated with their direct effect on prostate cancer.
View Article and Find Full Text PDFThe authors wish to make the following correction to this paper [1].[..
View Article and Find Full Text PDFMicroRNAs (miRNAs) are well established epigenetic modifiers. There is a lot of work being done to identify the evolutionary transfer of miRNAs both at intra- and interspecific levels. In this hypothesis-driven review, we have suggested a possible reason as to why miR-150 can be a promising diagnostic biomarker for prostate cancer using theories of evolution, bio-accumulation, and interspecific transfer of miRNAs.
View Article and Find Full Text PDFBackground: In situ hybridisation (ISH) is a robust method to determine the presence of mRNA for specific genes within a tissue. Ideally, positive and negative control tissues are used to determine probe specificity. However, this is not always possible, particularly for human genes where no knock-out controls exist.
View Article and Find Full Text PDFMilk from dairy cows contains the protein β-lactoglobulin (BLG), which is not present in human milk. As it is a major milk allergen, we wished to decrease BLG levels in milk by RNAi. In vitro screening of 10 microRNAs (miRNAs), either individually or in tandem combinations, identified several that achieved as much as a 98% knockdown of BLG.
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