encoding Shiga toxin subtype Stx2f causing human infections in England, 2015-2022.

Shiga toxin-producing (STEC) belong to a diverse group of gastrointestinal pathogens defined by the presence of Shiga toxin genes () of which there are at least ten subtypes (Stx1a-Stx1d and Stx2a-Stx2g). Initially thought to be associated with mild symptoms, more recently STEC encoding have been isolated from cases of haemolytic uraemic syndrome (HUS) and the clinical significance and public health burden require further investigation. We analysed clinical outcomes and genome-sequencing data linked to patients infected with STEC encoding- in England to assess the risk to public health.