Publications by authors named "Anouk Widmer"
Article Synopsis
- Complex karyotypes (CKTs) and highly complex karyotypes (hCKTs) are significant predictors of worse outcomes in chronic lymphocytic leukemia (CLL) when treated with chemoimmunotherapy, and their impact is further explored in venetoclax-based therapies.
- * In a study involving 895 patients, CKTs were linked to shorter progression-free survival (PFS) and overall survival (OS) in the CIT group, while hCKTs negatively affected PFS in the venetoclax group.
- * The findings suggest that karyotype analysis should be included in standard CLL diagnostics to better identify patients at high risk for poor treatment outcomes, supporting more personalized treatment approaches.
Article Synopsis
- The study investigates the effectiveness of venetoclax combined with anti-CD20 antibodies in fit patients with advanced chronic lymphocytic leukemia (CLL), compared to traditional chemoimmunotherapy.
- In a phase 3 trial with 926 participants, various treatment regimens were compared, emphasizing the primary goals of achieving undetectable minimal residual disease and prolonging progression-free survival.
- Results showed that venetoclax combinations significantly outperformed chemoimmunotherapy in terms of undetectable minimal residual disease rates and 3-year progression-free survival, especially in the venetoclax-obinutuzumab-ibrutinib group.
We assessed the accuracy of C-reactive protein (CRP) levels and lymphocyte counts to predict a mechanical complication (MC) after myocardial infarction (MI). Within 10 years, we identified 36 patients with 39 echocardiographically confirmed MC within 30 days of MI: ventricular septal defect (17 cases), papillary muscle rupture (10 cases), and left ventricular free wall rupture (12 cases). They were compared to 41 controls with an uncomplicated hospital course after MI.
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