Publications by authors named "Anouk Giulianelli"
Article Synopsis
- MDM2 and MDM4 are proteins that regulate the p53 tumor suppressor, often overexpressed in cancers, leading to clinical trials targeting their interaction with p53.
- A study of bone marrow samples from 111 patients with various types of leukemia found low protein levels of MDM2 and MDM4 in those with high marrow blasts (>5%), while mRNA levels remained similar across samples.
- The low protein expression of MDM2 and MDM4 was linked to worse survival outcomes, highlighting a disconnect between mRNA and protein levels and suggesting a reevaluation of using MDM2 and MDM4 inhibitors in advanced myeloid cancers.
