Publications by authors named "Anouck Haanappel"
Short-term outcomes of surgical treatment for primary ileocaecal Crohn's disease: Results of the Crohn's(urg) study, a multicentre, retrospective, comparative analysis between inflammatory and complicated phenotypes.
Colorectal Dis
July 2024
Aim: Recent evidence challenges the current standard of offering surgery to patients with ileocaecal Crohn's disease (CD) only when they present complications of the disease. The aim of this study was to compare short-term results of patients who underwent primary ileocaecal resection for either inflammatory (luminal disease, earlier in the disease course) or complicated phenotypes, hypothesizing that the latter would be associated with worse postoperative outcomes.
Method: A retrospective, multicentre comparative analysis was performed including patients operated on for primary ileocaecal CD at 12 referral centres.
Optimising surgical anastomosis in ileocolic resection for Crohn's disease with respect to recurrence and functionality: two international parallel randomized controlled trials comparing handsewn (END-to-end or Kono-S) to stapled anastomosis (HAND2END and the End2End STUDIES).
BMC Surg
February 2024
Article Synopsis
- This study focuses on comparing different types of surgical connections, called anastomoses, made after ileocolic resection in Crohn's disease patients, specifically looking at handsewn versus stapled techniques.
- The experiment involves a randomized controlled trial with two international studies in the Netherlands and Italy, aiming to determine which technique leads to less endoscopic disease recurrence and better gastrointestinal function at 6 months post-surgery.
- Primary outcomes include measuring endoscopic recurrence at 6 months and assessing secondary factors like morbidity, quality of life, and healthcare costs, with a goal of using 165 patients in the Netherlands and 189 in Italy for significant results.
Background: Surgical management for patients with inflammatory ileocecal Crohn's disease (CD) could be a reasonable alternative to second-line medical treatment.
Aim: To assess short and long-term outcomes of patients operated on for inflammatory, ileocecal Crohn's disease.
Methods: A retrospective analysis of patients intervened at four referral hospitals during 2012-2021 was performed.
Introduction: Pretreatment enlarged lateral lymph nodes (LLN) in patients with locally advanced low rectal cancer are predictive for local recurrences after neoadjuvant (chemo)radiotherapy (n(C)RT) followed by total mesorectal excision (TME). Not much is known of the impact on oncological outcomes when in addition malignant features are present in enlarged LLN.
Patients And Methods: A multicenter retrospective cohort study was conducted at five tertiary referral centers in the Netherlands and Australia.
In the West, pre-treatment abnormal lateral lymph nodes (LLN+) in patients with a low locally advanced rectal cancer (AJCC Stage III), are treated with neoadjuvant (chemo)radiotherapy (nCRT), without a lateral lymph node dissection (LLND). It has been suggested, however, that LLN+ patients have higher local recurrence (LR) rates than similarly staged patients with abnormal mesorectal lymph nodes only (LLN-), but no comparative data exist. Therefore, we conducted this international multi-center study in the Netherlands and Australia of Stage III rectal cancer patients with either LLN+ or LLN- to compare oncological outcomes from both groups.
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