Publications by authors named "Anouchka Bories"
Background: Intra-articular adipose tissues (IAATs) are involved in osteoarthritis (OA) pathophysiology. We hypothesize that mesenchymal cells residing in IAATs may account for the specific inflammatory and metabolic patterns in OA patients.
Methods: Adipocyte precursors (preadipocytes and dedifferentiated fat cells (DFATc)) from IAATs (infrapatellar and suprapatellar fat pads) and autologous subcutaneous adipose tissues (SCATs) were isolated from knee OA patients.
Article Synopsis
- Free-living amoebae provide an environment where bacteria like Mycobacterium abscessus can develop resistance and possibly become pathogenic.
- The study focused on the gene expression differences between M. abscessus in amoeba and murine macrophages, comparing it with the less pathogenic Mycobacterium chelonae.
- Findings revealed that certain upregulated genes in M. abscessus help it survive environmental stress and switch to different metabolic processes, and when these genes were manipulated, it affected the bacteria's virulence and survival in host cells.
What differentiates Mycobacterium abscessus from other saprophytic mycobacteria is the ability to resist phagocytosis by human macrophages and the ability to multiply inside such cells. These virulence traits render M. abscessus pathogenic, especially in vulnerable hosts with underlying structural lung disease, such as cystic fibrosis, bronchiectasis or tuberculosis.
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