Use of Financial Hardship as a Metric for Assessing Financial Toxicity in Surgical Trauma Patients.

Background: Financial toxicity is the detrimental impact of health care costs that must be mitigated to achieve universal health coverage. Catastrophic health expenditure (CHE) is widely used to measure financial toxicity but does not capture patient perspectives of unaffordable health care costs. Financial hardship (FH), a patient-reported outcome measure, is currently underutilized but may be an important adjunct metric.

Flap endonuclease 1 repairs DNA-protein cross-links via ADP-ribosylation-dependent mechanisms.

DNA-protein cross-links (DPCs) are among the most detrimental genomic lesions. They are ubiquitously produced by formaldehyde (FA), and failure to repair FA-induced DPCs blocks chromatin-based processes, leading to neurodegeneration and cancer. The type, structure, and repair of FA-induced DPCs remain largely unknown.

Development and Validation of a Deep Learning Model Based on MRI and Clinical Characteristics to Predict Risk of Prostate Cancer Progression.

Purpose To validate a deep learning (DL) model for predicting the risk of prostate cancer (PCa) progression based on MRI and clinical parameters and compare it with established models. Materials and Methods This retrospective study included 1607 MRI scans of 1143 male patients (median age, 64 years; IQR, 59-68 years) undergoing MRI for suspicion of clinically significant PCa (csPCa) (International Society of Urological Pathology grade > 1) between January 2012 and May 2022 who were negative for csPCa at baseline MRI. A DL model was developed using baseline MRI and clinical parameters (age, prostate-specific antigen [PSA] level, PSA density, and prostate volume) to predict the time to PCa progression (defined as csPCa diagnosis at follow-up).

Self-Reported Delayed Adverse Events and Flare Following COVID-19 Vaccination Among Patients With Autoimmune Rheumatic Disease (AIRD) in Malaysia: Results From the COVAD-2 Study.

Objectives: To determine the prevalence of self-reported delayed adverse events (DAEs), major AEs, and flares following COVID-19 vaccinations among patients with autoimmune rheumatic diseases (AIRDs) in Malaysia.

Methodology: An electronically validated survey from the COVID-19 vaccination in autoimmune diseases (COVAD) study group was distributed in July 2021 to patients with autoimmune diseases and healthy controls (HCs). The survey collected data on DAEs (any AE that persisted or occurred after 7 days of vaccination), any early or delayed major adverse events (MAEs), and flares following COVID-19 vaccination.

Genome wide landscaping of copy number variations for horse inter-breed variability.

Copy number variations (CNVs) have become widely acknowledged as a significant source of genomic variability and phenotypic variance. To understand the genetic variants in horses, CNVs from six Indian horse breeds, Manipuri, Zanskari, Bhutia, Spiti, Kathiawari and Marwari were discovered using Axiom Equine Genotyping Array. These breeds differed in agro-climatic adaptation with distinct phenotypic characters.

Assessment of Knowledge, Awareness, and Practices of Human Papillomavirus Infection and Vaccination Among Medical and Dental Students: A Cross-Sectional Study.

Introduction Human papillomavirus (HPV) is the most common causative agent for cervical cancer (CC) in women. Despite extensive initiatives, the acceptance and implementation of vaccinations have remained inadequate, hindering a significant impact on public health outcomes. This study aimed to provide a comprehensive assessment of the knowledge, awareness, and practices (KAP) scores of medical and dental students regarding HPV infection and vaccination.

Optimization of cutting temperature and surface roughness in CNC turning of Ti-6Al-4V alloy using response surface methodology.

This study investigates the optimization of cutting conditions for machining titanium alloy (Ti-6Al-4V) using Response Surface Methodology (RSM), with the goal of minimizing tool-chip interface temperature and surface roughness. The research focuses on key cutting parameters to investigate the most effective combinations for enhancing surface finish and reducing thermal impact during machining. The present study deals with the dry turning of Ti-6Al-4V alloy with carbide alloy inserts in a way to utilize the Analysis of Variance (ANOVA) to develop predictive models for minimum surface roughness and optimum temperature.

Distribution of extrapulmonary tuberculosis in CBNAAT samples received in a tertiary care hospital - A record-based study.

Background: Pulmonary tuberculosis (PTB) accounts for 85% of all reported tuberculosis cases globally. Extrapulmonary involvement can occur in isolation or along with a pulmonary focus as in the case of patients with disseminated tuberculosis (TB). EPTB can occur through hematogenous, lymphatic, or localized bacillary dissemination from a primary source, such as PTB and affects the brain, eye, mouth, tongue, lymph nodes of neck, spine, bones, muscles, skin, pleura, pericardium, gastrointestinal, peritoneum and the genitourinary system as primary and/or disseminated disease.

How depression impacts on road traffic accidents among older adults and elderly Indians: Evidence from large scale nationally representative survey.

Introduction: With increased urbanization the prevalence of important public health problems like road traffic accidents (RTA) and depression are surging. This study was aimed to determine the association between RTA and depression among Indian population aged ≥45 years.

Methods: Using Longitudinal Aging Study in India (LASI) dataset (April 2017-December 2018), we have conducted this study among older adults (45-59 years) and elderly (≥60 years) Indians.

Development of SNP for Species Identification With Special Focus on the Cryptic Species Complex of .

The genus in the North Atlantic comprises of long lived deep-waters species that have been extensively fished upon, and many stocks are severely depleted across the Atlantic. This is particularly evident for the species . In recent papers, cryptic species have been indicated within this genus and molecular markers are therefore needed to provide identification for the species, including the cryptic species as a basis for advice regarding management and rebuilding of the stocks.

Physical functioning trajectories over statutory retirement: a finnish occupational cohort study.

Background: The association of workload and performance with physical functioning is recognised among the ageing public sector workforce. The characteristics of working conditions and social- and health-related factors associated with physical functioning after statutory retirement are still unknown. Also, previous studies on changes in physical functioning have not used a person-oriented approach.

Prenatal exposure to particulates and anthropometry through 9 years of age in a birth cohort.

Background: Previous research observed links between prenatal air pollution and risk of childhood obesity but the timing of the exposure is understudied.

Aim: We examined prenatal particulate matter (PM, PM) exposure and child anthropometry.

Materials & Methods: Children's body mass index z-scores (zBMI) at 0-3 (N = 4370) and 7-9 (n = 1191) years were derived from reported anthropometry at paediatric visits.

Mercury tolerance and bioremediation potential of mountain soil bacteria: Insights from Darjeeling, containing elevated levels of mercury.

More and more research is now being focused on the mercury contamination of remote mountain environments. This study aimed to explore the mountain soil of Tiger Hill, Darjeeling, through the lens of its mercury tolerant bacterial microbiome to characterize regional mercury pollution and isolate strains with mercury bioremediation potential. The soil bacteria isolated from the region displayed an extreme tolerance to mercury at previously unseen levels of up to 7 mg/mL.

Magnetic vortex: Fundamental physics, developments, and device applications.

A magnetic vortex (MV) is one of the fundamental and topologically nontrivial spin textures in condensed matter physics. Magnetic vortices are usually the ground states in geometrically restricted ferromagnets with zero magnetocrystalline anisotropy. Magnetic vortices have recently been proposed for use in a variety of spintronics applications due to their resistance to thermal perturbations, flexibility in changing core polarity, simple patterning procedure, and potential uses in magnetic data storage with substantial density, sensors for the magnetic field, devices for logic operations, and other related fields.

Raman signatures of inversion symmetry breaking structural transition in quasi-1D compound, (TaSe4)3I.

The breaking of inversion symmetry combined with spin-orbit coupling, can give rise to intrigu- ing quantum phases and collective excitations. Here, we report systematic temperature dependent Raman scattering and theoretical calculations of phonon modes across the inversion symmetry- breaking structural transitions in a quasi-one-dimensional compound (TaSe4)3I. Our investigation revealed the emergence of three additional Raman-active modes in Raman spectra of the low- temperature (LT) non-centrosymmetric (NC) structure of the material.

Evaluation of Noise in Paediatric Dentistry and Change in Perception of Operators with Use of Ear Protection Devices.

Background: Noise sources in paediatric dental offices include machinery and children's cries and screams. Although the presence of occupational noise-induced hearing loss (ONIHL) among dental operators is established, preventive measures such as ear protection devices (EPDs) are not frequently employed as prophylactic intervention. The primary aim of this study was to quantitatively assess the noise levels in paediatric dental clinics and to qualitatively evaluate the operators' perception of noise with and without the use of EPDs.

Intentional Reimplantation Combining the Benefits of Leukocyte- and Platelet-rich Fibrin and Biodentine™ for the Treatment of a Large Periapical Cyst: A Case Report.

Background: This case report examines the efficacy of intentional reimplantation (IR) in endodontics and explores the increased interest driven by recent advancements in regenerative techniques.

Case Presentation: A 14-year-old male patient reported pain in the lower left back tooth (tooth #36). The radiographic assessment revealed a 4 mm × 4 mm periapical cyst.

Combining Thermogravimetry-Mass Spectrometry and Target Factor Analysis for Rapid Characterization of Volatiles from Degradation of Epoxy Paint.

Thermogravimetry coupled with simultaneous evolved gas analysis by mass spectrometry was used for discerning organic compounds released during the thermal degradation of paint whose chemical compositions are not readily accessible. Thermogravimetric analyses up to 600°C revealed distinct degradation patterns under inert and oxidative conditions. Significant degradation of paint initiates at around 360°C and concludes at 500°C in a nitrogen atmosphere.

Spatial land degradation vulnerability assessment in a plateau fringe river basin of Jharkhand, India.

This study assesses land degradation vulnerability in the Jainti River basin, Jharkhand, Eastern India, incorporating environmental, socio-economic, and soil health parameters. Using the fuzzy-analytical hierarchical process (AHP), fuzzy transformations and membership functions were applied to target land degradation. AHP determined the relative weight of each parameter based on parameter's relevance to land degradation.

Exploring the physiological, biochemical, and enzymatic responses of Vigna mungo varieties to Mungbean Yellow Mosaic India Virus (MYMIV) infection.

This study aims to enhance sustainable disease management in black gram by identifying varieties resistant to Mungbean Yellow Mosaic India Virus (MYMIV). We screened sixteen black gram genotypes, assessing physiological, biochemical and enzymatic basis. Results revealed a range of resistance levels, with PANT URD-19 showing the highest resistance (PDI 0.

Benchmark computations of nearly degenerate singlet and triplet states of N-heterocyclic chromophores. II. Density-based methods.

In this paper, we demonstrate the performance of several density-based methods in predicting the inversion of S1 and T1 states of a few N-heterocyclic triangulene based fused ring molecules (popularly known as INVEST molecules) with an eye to identify a well performing but cost-effective preliminary screening method. Both conventional linear-response time-dependent density functional theory (LR-TDDFT) and ΔSCF methods (namely maximum overlap method, square-gradient minimization method, and restricted open-shell Kohn-Sham) are considered for excited state computations using exchange-correlation (XC) functionals from different rungs of Jacob's ladder. A well-justified systematism is observed in the performance of the functionals when compared against fully internally contracted multireference configuration interaction singles and doubles and/or equation of motion coupled-cluster singles and doubles (EOM-CCSD), with the most important feature being the capture of spin-polarization in the presence of correlation.

Nature's defense against emerging neurodegenerative threats: Dynamic simulation, PCA, DCCM identified potential plant-based antiviral lead targeting borna disease virus nucleoprotein.

The rare zoonotic Borna disease virus (BDV) causes fatal neurological disease in various animals, with a high mortality rate exceeding 90% in central Europe. However, unlike most viruses, it establishes persistent infections within the host cell nucleus, hindering treatment. As successful BDV treatments remain elusive, the researchers turned to a computational approach, utilizing molecular docking, ADME/T, post-docking MMGBSA, MD simulation, DCCM, and PCA to identify promising phytochemical drug candidates targeting the BDV Nucleoprotein (PDB ID: 1N93).

Toxic Effects of Lead Exposure on Freshwater Climbing Perch, , and Bioremediation Using Leaf Powder.

The acute and chronic toxicity of lead to was determined in this study using static replacement bioassay testing. During the chronic toxicity studies, an experiment on the bioremediation of lead toxicity using leaf powder was conducted. The 96 h LC values of lead for was 1.

Machine learning-based identification of animal feeding operations in the United States on a parcel-scale.

The increasing global demand for meat and dairy products, fueled by rapid industrialization, has led to the expansion of Animal Feeding Operations (AFOs) in the United States (US). These operations, often found in clusters, generate large amounts of manure, posing a considerable risk to water quality due to the concentrated waste streams they produce. Accurately mapping AFOs is essential for effective environmental and disease management, yet many facilities remain undocumented due to variations in federal and state regulations.