Publications by authors named "Anoop Singh"

This study evaluates the efficacy of garbage enzyme (GE) in bioremediation to reduce pollutants in sewage drains that discharge into the natural streams and rivers. Garbage enzyme is prepared with help of brown sugar, fruit, vegetable wastes, and water in the proportion 1:3:10 (by weight), which is then applied to the samples collected from various drainage sites in Jaunpur district, Uttar Pradesh, India. Different concentrations of GE (ranging from 0% to 20%) are mixed with sewage to assess pollution reduction.

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Introduction: The study aims to assess the procedural outcomes and follow-up after transcatheter closure of ventricular septal defects (VSDs) in children utilizing the Konar-MF™ occluder (Lifetech Scientific, Shenzhen, PRC) device.

Materials And Methods: Clinical features, demographic characteristics, and follow-up findings of children undergoing percutaneous VSD device closure were retrospectively analyzed from the medical records.

Results: Fifty-seven patients underwent VSD closure using the Konar-MF occluder between January 2019 and April 2023.

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The escalating threat of antimicrobial resistance has become a global health crisis. Therefore, there is a rising momentum in developing biomaterials with self-sanitizing capabilities and inherent antibacterial properties. Despite their promising antimicrobial properties, metal nanoparticles (MNPs) have several disadvantages, including increased toxicity as the particle size decreases, leading to oxidative stress and DNA damage that need consideration.

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Background: Giant prolactinomas are rare; among them, the amyloidogenic variant, prolactinomas with extensive spherical amyloid deposits, are rare, with only 30 cases reported with recommendations of surgical management contrary to the routine prolactinoma's medical management.

Case Description: We report here a case of giant amyloidogenic prolactinoma in a 32-year-old male patient who had a very atypical presentation in terms of clinical, radiological, and pathological features and responded to dopamine agonist therapy like a normal prolactinoma.

Conclusion: Amyloidogenic giant prolactinomas are rare.

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Introduction: The Maternal Mortality Rate (MMR) is one of the most important health indicators of a country. In India, MMR has decline from 130 to 113 per 100,000 live births between 2014 and 2018, however, there are wide disparities in utilization of maternal health services (MHS) among different states and across different socioeconomic groups within the states. Although the government is providing MHS through various health programs in India, there are several non medical factors leading to the underutilization of MHS services.

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To achieve better-repurposed motifs, saccharin has been merged with biocompatible sugar molecules via a 1,2,3-triazole linker, and ten novel 1,2,3-triazole-appended saccharin glycoconjugates were developed in good yield by utilizing modular CuAAC click as regioselective triazole forming tool. The docking study indicated that the resulting hybrid molecules have an overall substantial interaction with the CAXII macromolecule. Moreover, the galactose triazolyl saccharin analogue 3h has a binding energy of -8.

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We report a first and interesting case of balloon-assisted deployment of a dislodged coronary stent. While performing a calcified left circumflex coronary artery (LCX) intervention, the drug-eluting coronary stent was dislodged in the osteoproximal segment of the calcified and tortuous LCX. The dislodged stent was rewired, progressively dilated with multiple balloons and, finally, a larger, balloon-mounted stent was pushed forward, positioned across the coronary lesion and deployed, resulting in distal thrombolysis in myocardial infarction (TIMI) III flow with good angiographic results.

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Unilateral absence of pulmonary artery (UAPA) can be either isolated or associated with other congenital cardiac defects. It is a rare congenital lesion with a diverse clinical presentation. We present a case of absent right pulmonary artery and large patent ductus arteriosus (PDA) with severe unilateral pulmonary hypertension.

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Article Synopsis
  • - The demand for advanced gas sensors is growing across fields like environmental monitoring, healthcare, and industrial safety, prompting research into materials like ternary alloy indium aluminum nitride (InAlN) for improved sensing capabilities.
  • - This study focuses on creating and analyzing InAlN nanorods on sapphire substrates, utilizing magnetron sputter epitaxy to control indium composition and explore their effectiveness for detecting acetone, a key gas in medical and industrial contexts.
  • - Findings show that these InAlN nanorods can sense acetone effectively, achieving a 2.33% sensor response at 600 ppm concentration with a quick 18-second response time, highlighting their potential for various practical applications.
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Tea, the major beverage worldwide, is one of the oldest commercial commodities traded from ancient times. Apart from many of its advantages, including health, socio-economic, climatic, and agro-ecological values, FAO has recognized that the tea value chain covering its growth in the field, processing and marketing, and finally, the hot cup at the user's hand needs to be made sustainable during all these stages. Tea generates a lot of waste in different forms in different stages of its growth and processing, and these wastes, if not managed properly, may cause environmental pollution.

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Background: Suspicious gallbladder wall thickening encountered during laparoscopic cholecystectomy poses challenges in its management. This study aims to address this problem by proposing a technique that involves laparoscopic transhepatic needle decompression and modified cystic plate cholecystectomy.

Methods: In this report, we describe the case of a 36-year-old female with symptomatic gallstone disease and ultrasound findings of a well-distended gallbladder with a uniform wall thickness.

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Rapid urban population growth, the urbanization of poverty, and the proliferation of slums are being driven to a great extent by this dynamic form of globalization. Consequently, the multifaceted effects of globalization on the poor and low-income populations in the cities need to be better understood in this context, both at the individual level and within the community. Therefore, the present study was conducted to highlight the various determinants affecting the lives and enhancing the vulnerability of the dwellers of four slum settlements present in various areas of Jammu City, India.

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The need for wearable bioelectronics continues to grow, and this technology might significantly alter the medical field. In order to diagnose and treat a patient, conventional medicine takes a "reactive" approach and waits for symptoms to appear first. Therefore, it is preferable to progress toward continuous non-invasive wearable biomonitoring, a preventative strategy that may assist individuals in diagnosing or treating illnesses at the earliest stages, sometimes before any outward symptoms have appeared.

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Article Synopsis
  • Calmodulinopathy is caused by mutations in CALM genes and leads to serious arrhythmias, particularly in young people; the ICalmR aims to connect clinical symptoms with molecular causes.
  • The ICalmR has gathered data from 140 patients, showing a notable presence of CALM-LQTS and CALM-CPVT, and has observed a decrease in the frequency of serious cardiac events compared to past data.
  • The condition presents a wide range of symptoms, from severe arrhythmias to no symptoms at all; while therapy options are limited and based on current practices, management often involves medication and devices like defibrillators.
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Bioelectrochemical systems (BES) have emerged as a sustainable and highly promising technology that has garnered significant attention from researchers worldwide. These systems provide an efficient platform for the removal and recovery of valuable products from wastewater, with minimal or no net energy loss. Among the various types of BES, microbial fuel cells (MFCs) are a notable example, utilizing microbial biocatalytic activities to generate electrical energy through the degradation of organic matter.

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To develop a better chemotherapeutically potential candidate for lung cancer treatment and cure with repurposed motifs, quinine has been linked with biocompatible CuAAC-inspired regioselective 1,2,3-triazole linker and a series of ten novel 1,2,3-triazolyl-9-quinine conjugates have been developed by utilizing click conjugation of glycosyl ether alkynes with 9-epi-9-azido-9-deoxy-quinine under standard click conditions. In parallel, the docking study indicated that the resulting conjugates have an overall appreciable interaction with ALK-5 macromolecules. Moreover, the mannose-triazolyl conjugate exhibited the highest binding interactions of -7.

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Bacillus anthracis Ser/Thr protein kinase PrkC is necessary for phenotypic memory and spore germination, and the loss of PrkC-dependent phosphorylation events affect the spore development. During sporulation, Bacillus sp. can store 3-Phosphoglycerate (3-PGA) that will be required at the onset of germination when ATP will be necessary.

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Over the course of the last several decades, nanotechnology has garnered a growing amount of attention as a potentially valuable technology that has significantly impacted the food industry. Nanotechnology helps in enhancing the properties of materials and structures that are used in various fields such as agriculture, food, pharmacy, and so on. Applications of nanotechnology in the food market have included the encapsulation and distribution of materials to specific locations, the improvement of flavor, the introduction of antibacterial nanoparticles into food, the betterment of prolonged storage, the detection of pollutants, enhanced storage facilities, locating, identifying, as well as consumer awareness.

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Mycotoxins are naturally occurring toxic secondary metabolites produced by fungi in cereals and foodstuffs during the stages of cultivation and storage. Electrochemical biosensing has emerged as a rapid, efficient, and economical approach for the detection and quantification of mycotoxins in different sample media. An electrochemical biosensor consists of two main units, a recognition receptor and a signal transducer.

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Introduction: Physicians need adequate physical exam skills. Unfortunately, interns have variable physical exam skills, and teaching is often limited to rounds, an inconsistent setting. Physical exam skills, particularly those involving auscultation, require practice.

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Article Synopsis
  • * Concerns about food competition, high production costs, and environmental impacts necessitate exploring new feedstocks and technologies for sustainable biodiesel production.
  • * Bioengineering advancements, including genetic engineering and waste valorization, offer promising methods for producing cost-effective and eco-friendly biodiesel while enhancing its commercialization potential.
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Wearable sensors and invasive devices have been studied extensively in recent years as the demand for real-time human healthcare applications and seamless human-machine interaction has risen exponentially. An explosion in sensor research throughout the globe has been ignited by the unique features such as thermal, electrical, and mechanical properties of graphene. This includes wearable sensors and implants, which can detect a wide range of data, including body temperature, pulse oxygenation, blood pressure, glucose, and the other analytes present in sweat.

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The primary source of heavy metal discharge into the water is human activity and urbanization near water bodies. Contamination of drinking water sources with heavy metals has a harmful impact on the environment and human health. The most commonly used heavy metals are Zinc (Zn), Copper (Cu), Nickel (Ni), Lead (Pb), Cadmium (Cd), Chromium (Cr), Arsenic (As), Mercury (Hg), etc.

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  • This study evaluates the accuracy of the Xpert MTB/RIF Ultra test using stool samples to detect tuberculosis (TB) and systematically reviews its performance across various sample types through meta-analysis.
  • Findings reveal that Xpert MTB/RIF Ultra achieved 100% sensitivity for smear-negative pulmonary TB in stool samples, with lower sensitivities for cervical lymph node and abdominal TB, while maintaining 100% specificity overall.
  • Among all tested sample types, urine was found to be the most effective for diagnosing extrapulmonary TB (EPTB), suggesting that stool could serve as a valuable non-invasive option for TB testing.
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Cellulose, a bio-derived polymer, is widely used in food packaging, dye removal, coatings, and solid-supported catalysis. Heterogeneous catalysts play a critical role in environmental remediation. In this context, the demand for green and cost-effective catalysts has rapidly increased.

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