Publications by authors named "Anoop Kumar G Velikkakath"

Article Synopsis
  • Drug resistance is a major challenge in treating head and neck cancers, prompting the development of a new platform to visualize and analyze the molecular changes associated with this resistance.
  • Researchers identified 2364 differentially expressed molecules linked to drug resistance in HNC, including various types of RNAs and proteins, with 255 identified as key driver genes.
  • A publicly-accessible database, HNCDrugResDb, was created to help users explore molecular alterations and signaling pathways involved in drug resistance, with tools to predict resistance likelihood based on gene expression, aiming to enhance future drug discovery and personalized medicine.
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Exosomes, which are nano-sized transport bio-vehicles, play a pivotal role in maintaining homeostasis by exchanging genetic or metabolic information between different cells. Exosomes can also play a vital role in transferring virulent factors between the host and parasite, thereby regulating host gene expression and the immune interphase. The association of inflammation with disease development and the potential of exosomes to enhance or mitigate inflammatory pathways support the notion that exosomes have the potential to alter the course of a disease.

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Mutations in the ubiquitin ligase PRKN (parkin RBR E3 ubiquitin protein ligase) are associated with Parkinson disease and defective mitophagy. Conceptually, PRKN-dependent mitophagy is classified into two phases: 1. PRKN recruits to and ubiquitinates mitochondrial proteins; 2.

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The redox-active transition metals such as copper, iron, chromium, vanadium, and silica are known for its ROS generation via mechanisms such as Haber-Weiss and Fenton-type reactions. Nanoparticles of these metals induce oxidative stress due to acellular factors owing to their small size and more reactive surface area, leading to various cellular responses. The intrinsic enzyme-like activity of nano vanadium has fascinated the scientific community.

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Macroautophagy is an intracellular degradation system by which cytoplasmic materials are enclosed by the autophagosome and delivered to the lysosome. Autophagosome formation is considered to take place on the endoplasmic reticulum and involves functions of autophagy-related (Atg) proteins. Here, we report the identification and characterization of mammalian Atg2 homologues Atg2A and Atg2B.

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