Long-term monitoring of Paenibacillus larvae, causative agent of American Foulbrood, in Uruguay.

Paenibacillus larvae is the causative agent of American Foulbrood (AFB), the most severe bacterial disease affecting honey bee (Apis mellifera) larvae. It was first reported in Uruguay in 1999. Here, we summarize the monitoring strategy carried out from 2001 to date, based on nationwide surveys sampling honey from colonies (2001/2002, 2011, 2021) or from honey storage tanks (2014-2019).

Supplementation of honey bee production colonies with a native beneficial microbe mixture.

Honey bee colonies form a complex superorganism, with individual and social immune defences that control overall colony health. Sometimes these defences are not enough to overcome infections by parasites and pathogens. For that reason, several studies have been conducted to evaluate different strategies to improve honey bee health.

Bladder exstrophy: Modern staged repair experience in our institution.

Introduction: Bladder exstrophy is a major malformation in paediatric urology. The treatment results are not still completely satisfactory, and their management is an enormous problem in Sub-Saharan Africa. While outlining our challenges, we report our management experience to improve our results.

Regulation of arachidonic acid production by intracellular calcium in parathyroid cells: effect of extracellular phosphate.

The action of extracellular calcium on the calcium receptor in parathyroid cells results in activation of phospholipase C (PLC), PLD, and PLA(2). The PLA(2)-arachidonic acid (AA) intracellular signaling pathway mediates inhibition of parathyroid hormone (PTH) secretion. In addition, stimulation of the calcium receptor produces increases in intracellular calcium levels.

Effect of high extracellular phosphate concentration on arachidonic acid production by parathyroid tissue in vitro.

Recent in vivo and in vitro studies show that high phosphate directly stimulates parathyroid hormone (PTH) secretion. However, little is known about the intracellular signaling system involved in the regulation of PTH secretion by extracellular phosphate. High extracellular calcium is coupled to the activation of phospholipase A(2) (PLA(2)) and the formation of arachidonic acid (AA), a potent inhibitor of PTH release.