Publications by authors named "Anokhi Cifuentes"
Article Synopsis
- The study investigates the relationship between labor duration, mode of delivery (cesarean vs. vaginal), and long-term maternal mortality among mothers from the Collaborative Perinatal Project cohort.
- Findings indicate that 5.9% of the participants underwent a cesarean delivery, and those who had cesarean births were generally older, had higher BMI, and more pre-existing health conditions compared to those with vaginal deliveries.
- The results show that having a cesarean delivery is significantly associated with an increased risk of all-cause mortality, particularly among first-time mothers (nulliparas).
VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer immunotherapy. However, its effective targeting has been impeded by issues such as rapid clearance and cytokine release syndrome observed with previous VISTA antibodies. Here we demonstrate that SNS-101, a newly developed pH-selective VISTA antibody, addresses these challenges.
View Article and Find Full Text PDFObjectives: Despite their efficacy, some immunotherapies have been shown to induce immune-related adverse events, including the potentially life-threatening cytokine release syndrome (CRS), calling for reliable and translational preclinical models to predict potential safety issues and investigate their rescue. Here, we tested the reliability of humanized BRGSF mice for the assessment of therapeutics-induced CRS features in preclinical settings.
Methods: BRGSF mice reconstituted with human umbilical cord blood CD34 cells (BRGSF-CBC) were injected with anti-CD3 antibody (OKT3), anti-CD3/CD19 bispecific T-cell engager Blinatumomab, or VISTA-targeting antibody.