Publications by authors named "Anny Cupo"
Coxiella burnetii is an intracellular bacterium that causes a worldwide zoonosis, the Q fever. Currently, to diagnose the infection in ruminants, whole cell antigens-based ELISAs are used. In this study a heat shock protein, the HspB, was evaluated for its ability to be recognized by the goat immune system and its capacity to sign a stage of infection.
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- Psalmotoxin 1 is a peptide from the South American tarantula that effectively reduces various types of pain in rodents, including thermal and neuropathic pain.
- It works by blocking a specific ion channel (acid-sensing ion channel 1a), which activates the body's natural pain-relieving system (endogenous enkephalin pathway).
- The pain-relief effects of Psalmotoxin 1 can be inhibited by certain opioid receptor blockers, and are absent in genetically modified mice lacking the Penk1 gene.
Determination of ddATP levels in human immunodeficiency virus-infected patients treated with dideoxyinosine.
Antimicrob Agents Chemother
February 2004
Clinical failures of the highly active antiretroviral therapy could result from inefficient intracellular concentrations of antiviral drugs. The determination of drug contents in target cells of each patient would be useful in clinical investigations and trials. The purpose of this work was to quantify the intracellular concentration of ddATP, the active metabolite of dideoxyinosine (ddI), in peripheral blood mononuclear cells (PBMCs) of human immunodeficiency virus (HIV)-infected patients treated with ddI.
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