Publications by authors named "Annmarie A Bosco"
Article Synopsis
- Methotrexate (MTX) toxicity is influenced by factors like dosing frequency, dosage, and administration route, with renal impairment worsening the toxicity.
- Low-dose MTX overdoses are usually safe, but repeated doses and higher doses increase toxicity risk, necessitating different treatments with folinic acid depending on the scenario.
- Glucarpidase can quickly reduce MTX levels in severe cases, especially intrathecal poisoning, but is costly and limited in availability; other supportive therapies like hydration and haemodialysis may also be helpful.
A patient with spontaneous hemorrhage from multiple body sites was found to have markedly prolonged international normalized ratio (INR) and activated partial thromboplastin times (aPTT) with incomplete correction of aPTT on mixing studies using normal plasma. The cause of this severe hemorrhage was due to a specific factor X inhibitor. No underlying or associated diseases were found.
View Article and Find Full Text PDFAggressive natural killer cell leukemia (ANKL) is a very rare condition and when reported occurs almost exclusively in adults. We report a pediatric case of ANKL that presented with hemophagocytic syndrome, preceding the onset of leukemia by 12 weeks. Clinical and laboratory findings are discussed, along with morphology, immunophenotyping and cytogenetics, as well as the association with Epstein-Barr virus (EBV).
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