Publications by authors named "Annina Kemmer"
Miniaturized cultivation systems offer the potential to enhance experimental throughput in bioprocess development. However, they usually lack the miniaturized pumps necessary for fed-batch mode, which is commonly employed in industrial bioprocesses. An alternative are enzyme-mediated glucose release systems from starch-derived polymers, facilitating continuous glucose supply.
View Article and Find Full Text PDFRobotic facilities that can perform advanced cultivations (e.g., fed-batch or continuous) in high throughput have drastically increased the speed and reliability of the bioprocess development pipeline.
View Article and Find Full Text PDFHigh-Throughput Expression of Inclusion Bodies on an Automated Platform.
Methods Mol Biol
January 2023
Article Synopsis
- In bioprocesses aimed at producing recombinant proteins as inclusion bodies, the upstream process significantly impacts downstream operations, particularly in cell disruption and inclusion body quality.
- Optimizing fed-batch processes is crucial, but traditional methods like shake flasks and multiwell plates are labor-intensive and costly.
- An automated platform for E. coli fed-batch cultivations in minibioreactors facilitates high-throughput experiments with real-time monitoring, enhancing the efficiency and robustness of upstream process development.