Association of Hormone Therapy With Depression During Menopause in a Cohort of Danish Women.

Importance: During menopause, the levels of estrogen and progesterone decrease and 60% to 70% of women experience menopausal symptoms, including mood disturbances. The latter might be prevented by hormone therapy (HT), yet some studies have suggested that use of HT might be associated with increased risk of depression.

Objective: To examine whether use of HT during menopause was associated with a subsequent diagnosis of depression.