Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival.

Mg regulates many physiological processes and signalling pathways. However, little is known about the mechanisms underlying the organismal balance of Mg. Capitalizing on a set of newly generated mouse models, we provide an integrated mechanistic model of the regulation of organismal Mg balance during prenatal development and in adult mice by the ion channel TRPM6.