Proof-of-principle that a decoy virus protects oncolytic measles virus against neutralizing antibodies.

Background: Attenuated oncolytic measles virus (OMV) is a promising antitumor agent in early-phase clinical trials. However, pre-existing immunity against measles might be a hurdle for OMV therapy.

Methods: OMV was inactivated with short-wavelength ultraviolet light (UV-C).