Publications by authors named "Annika V Rademacher"
Article Synopsis
- The study focuses on Kv3.2, a potassium channel crucial for high-frequency brain firing and efficient action potential generation, examining its genetic variations linked to epilepsy.
- Researchers analyzed clinical data and functional characteristics of Kv3.2 variants found in patients with different types of epilepsy, including cases like genetic generalized epilepsy and severe developmental epilepsy.
- Results revealed that out of 18 identified variants, 10 were new and linked to severe epilepsy forms, leading to significant insights about Kv3.2's involvement in epilepsy and its role in regulating brain activity.
Larotrectinib can be effective in patients with ETV6-NTRK3–positive B-cell lymphoblastic leukemia, inducing prolonged molecular remission. Single-agent tyrosine kinase inhibitor treatment could be a valuable treatment option in subgroups of kinase fusion–positive ALL patients.
View Article and Find Full Text PDF