Publications by authors named "Annika Jaretzke"
Mol Carcinog
December 2019
Article Synopsis
- Syndecan-1 (CD138) is a protein expressed in both normal and cancerous tissues and is important for understanding its role in breast cancer prognosis and as a treatment target with Indatuximab.
- A study of 1,535 breast cancer specimens showed that while normal tissue had CD138 on cell membranes, cancer tissues often lost this membrane expression, with varying levels of cytoplasmic and stromal expression found instead.
- The presence of cytoplasmic CD138 staining was associated with aggressive cancer features and poor survival, while stromal positivity correlated with better outcomes, highlighting the complex role of CD138 in breast cancer prognosis.
