Publications by authors named "Annika Glatzel"
Article Synopsis
- Thyroid disease impacts energy metabolism, temperature control, and anxiety, primarily through thyroid hormone receptor α1 (TRα1) in the brain, but the exact brain areas involved remain unclear.
- Researchers used PET-CT scans to find the most affected brain region, the zona incerta (ZI), and inhibited TRα1 signaling there to study its effects on metabolism and behavior in mice.
- The inhibition led to increased energy expenditure without affecting body temperature regulation, and heightened glucocorticoid levels were observed, indicating a link between altered thyroid hormone signaling in the ZI and stress responses, but not temperature control.
For neurodegenerative diseases such as Huntington's disease (HD), early diagnosis is essential to treat patients and delay symptoms. Impaired olfaction, as observed as an early symptom in Parkinson´s disease, may also constitute a key symptom in HD. However, there are few reports on olfactory deficits in HD.
View Article and Find Full Text PDFThe literature describes a close correlation between metabolic disorders and abnormal immune responses, like low-grade inflammation (LGI), which may be one mechanistic link between obesity and various comorbidities, including non-alcoholic fatty liver disease (NAFLD). In our study, we investigated the influence of dietary composition on obesity-derived LGI in the liver. We used a dietary induced obesity mouse model of C57BL/6J mice fed with high fat diet (HFD, 60% fat, 20% protein, 20% carbohydrates) and two different controls.
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