Publications by authors named "Annika Bohner"
Background/aims: Common genetic variations in vitamin D metabolism are associated with liver stiffness. Whether these genes are implicated in hepatic steatosis remains unclear. Here we aimed to analyse the association of common vitamin D pathway gene variants with liver steatosis.
View Article and Find Full Text PDFComplement factor C5a has two known receptors, C5aR, which mediates proinflammatory effects, and C5L2, a potential C5a decoy receptor. We previously identified C5a/C5aR signaling as a potent profibrotic pathway in the kidney. Here we tested for the first time the role of C5L2 in renal fibrosis.
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- - The study explores the relationship between liver fibrosis and the development of hepatocellular carcinoma (HCC), highlighting the role of Toll-like receptor (TLR) 4 and interleukin (IL) 6 in HCC promotion, using a mouse model induced by diethylnitrosamine (DEN).
- - Researchers created ABCB4-deficient mice crossed with TLR4-deficient mice to assess how the absence of these proteins affects liver injury and tumor formation after DEN exposure.
- - The results show that TLR4 deficiency leads to reduced liver inflammation, apoptosis, and cell proliferation, resulting in smaller and fewer tumors in conjunction with ABCB4 deficiency, indicating a potential pathway to mitigate HCC development in
The mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) and the zinc finger transcription factor Kruppel-like factor-4 (KLF4) are involved in the regulation of redox homeostasis, apoptosis and cell proliferation. We have shown that estrogen exerts antioxidative actions via induction of MnSOD in cultured rat aortic vascular smooth muscle cells (VSMC). The purpose of the present study was to investigate whether estrogen inhibits VSMC proliferation via alteration of KLF4 and MnSOD expression.
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