Publications by authors named "Annika Ballast"
Pediatric high-grade gliomas of the subclass MYCN (HGG-MYCN) are highly aggressive tumors frequently carrying MYCN amplifications, TP53 mutations, or both alterations. Due to their rarity, such tumors have only recently been identified as a distinct entity, and biological as well as clinical characteristics have not been addressed specifically. To gain insights into tumorigenesis and molecular profiles of these tumors, and to ultimately suggest alternative treatment options, we generated a genetically engineered mouse model by breeding hGFAP-cre::Trp53::lsl-MYCN mice.
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- Researchers found that two important genes, CREBBP and MYCN, are often changed in brain tumors like glioma and medulloblastoma, which may work together to cause these tumors.
- They created special mice that lost CREBBP and had extra MYCN in their brain cells, and these mice developed aggressive brain tumors within eight months.
- The scientists discovered that the tumors likely started from a specific type of brain stem cell, showing that the messed-up versions of these genes can help make tumors grow faster.