Publications by authors named "Anniina Tervi"
Article Synopsis
- Puumala virus (PUUV) can lead to serious illnesses like Hemorrhagic Fever with Renal Syndrome, but the genetic factors affecting disease severity in humans are not well understood.
- A genome-wide association study using data from 2227 cases helped identify significant associations at the Human Leukocyte Antigen (HLA) locus and the ERAP1 gene, which are important for immune response.
- The study found a specific genetic variant (rs26653) in the ERAP1 gene and identified associations with several HLA alleles that suggest how these genetic factors may influence susceptibility to severe PUUV infections.
Article Synopsis
- * A meta-analysis identified eight genetic loci linked to Raynaud's syndrome, with specific genes like ADRA2A, NOS3, and IRX1 showing important roles in blood vessel behavior and gene expression.
- * The research utilized CRISPR gene editing and functional assays, revealing how these genes influence blood vessel contraction in response to cold, emphasizing the complexity of genes in understanding this syndrome.
Cancer risk is influenced by inherited mutations, DNA replication errors, and environmental factors. However, the influence of genetic variation in immunosurveillance on cancer risk is not well understood. Leveraging population-level data from the UK Biobank and FinnGen, we show that heterozygosity at the -II loci is associated with reduced lung cancer risk in smokers.
View Article and Find Full Text PDFBackground: Poor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor sleep and respiratory infections has remained unclear. We examined if poor sleep contributes as a causal risk factor to respiratory infections.
Methods: We used data on insomnia, influenza and upper respiratory infections (URIs) from primary care and hospital records in the UK Biobank (N ≈ 231,000) and FinnGen (N ≈ 392,000).
Article Synopsis
- Tuberculosis is a major global public health issue, causing over 1 million deaths annually, with many cases remaining untreated or resistant to treatment.
- Researchers aimed to uncover genetic risk factors and biological mechanisms related to tuberculosis using data from the FinnGen study, which included 1,895 diagnosed individuals.
- The study found specific HLA genetic variants linked to tuberculosis risk, particularly protective and predisposing alleles, and confirmed that lifestyle factors like smoking also increase the likelihood of developing the disease.
Article Synopsis
- Poor sleep is linked to higher risks of infections and increased mortality, but previous studies struggled to show a direct causal relationship between chronic sleep issues and respiratory infections.
- * The research aimed to determine if chronic poor sleep could be a causal factor for respiratory infections, including influenza and COVID-19, using large population data from the UK Biobank and FinnGen.
- * Results revealed that insomnia significantly increases the risk of various respiratory infections, confirming that chronic poor sleep acts as a causal risk factor for conditions like influenza and COVID-19 hospitalization.