Publications by authors named "Annie Wapniarski"
Article Synopsis
- * Researchers evaluated 140 participants using both traditional methods (qPCR and cryptococcal antigen tests) and advanced techniques (metagenomic next-generation sequencing) to identify infections like cerebral toxoplasmosis and cryptococcal meningitis.
- * Results showed that only 34% were diagnosed with an infection using any method, indicating the need for improved diagnostic tests to better detect central nervous system infections in this vulnerable population.
Background: Unbiased high-throughput sequencing (HTS) has enabled new insights into the diversity of agents implicated in central nervous system (CNS) infections. The addition of positive selection capture methods to HTS has enhanced the sensitivity while reducing sequencing costs and complexity of bioinformatic analysis. Here we report the use of virus capture based sequencing for vertebrate viruses (VirCapSeq-VERT) and bacterial capture sequencing (BacCapSeq) in investigating CNS infections.
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