Publications by authors named "Annie L W Eis"
Article Synopsis
- Many infants with congenital heart defects experience chronic low oxygen levels after surgery, prompting heart adaptations through specific protein signaling pathways.
- Research found that the heat shock protein Hsp70i is significantly increased in chronically hypoxic infant hearts and changes its location within cells, while another heat shock protein, Hsc70, remains unaffected.
- The study indicates that protein kinases, including specific types associated with stress responses, play a crucial role in regulating the distribution and levels of Hsp70i in response to low oxygen, highlighting its importance in how these hearts adapt to hypoxia.
Increased prostaglandin (PG) synthesis by fetal membranes occurs at parturition. PGE(2) synthesis from arachidonic acid involves multiple enzymes and two isoforms of the terminal enzyme of this biosynthetic pathway, PGE synthase (PGES), were recently identified. Cytosolic PGES (cPGES) is identical to the heat shock protein 90 chaperone, p23, and is reportedly functionally coupled to constitutive PG endoperoxide H synthase-1.
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