Publications by authors named "Annie L Neild"
To understand how macrophages (Mphi) activated with IFN-gamma modulate the adaptive immune response to intracellular pathogens, the interaction of IFN-gamma-treated bone marrow-derived murine Mphi (BMphi) with Legionella pneumophila was investigated. Although Legionella was able to evade phagosome lysosome fusion initially, and was capable of de novo protein synthesis within IFN-gamma-treated BMphi, intracellular growth of Legionella was restricted. It was determined that activated BMphi infected with Legionella suppressed IFN-gamma production by Ag-specific CD4 and CD8 T cells.
View Article and Find Full Text PDFIntracellular pathogens can manipulate host cellular pathways to create specialized organelles. These pathogen-modified vacuoles permit the survival and replication of bacterial and protozoan microorganisms inside of the host cell. By establishing an atypical organelle, intracellular pathogens present unique challenges to the host immune system.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how dendritic cells (DCs) interact with the intracellular pathogen Legionella pneumophila, showing that DCs can limit its growth, unlike other immune cells.
- The research found that after DCs engulf Legionella, its phagosomes transform into organelles derived from the endoplasmic reticulum (ER), but this doesn't prevent Legionella antigens from being presented on MHC class II molecules.
- Ultimately, the study highlights the role of DCs in presenting Legionella proteins to T cells, suggesting that their ability to control Legionella growth could be key to triggering effective immune responses against such vacuolar pathogens.