Publications by authors named "Annie Knight"
Background: Depression is common among people with inflammatory bowel disease (IBD), though the causes remain unclear. We conducted a cross-sectional study to investigate the role of emotional processing biases in contributing to depression among people with IBD.
Materials And Methods: One hundred and twenty outpatients with IBD were recruited and: (a) completed questionnaires to record: age, sex, social support, socioeconomic status, anxiety and depression (n = 104), (b) underwent assessments of biases in emotional recognition (n = 112), emotional memory and reinforcement learning (c) had recorded from clinical records: type of IBD, duration of IBD, IBD activity and (d) provided blood for high-sensitivity C-reactive protein levels (n = 99).
The management of patients with autoimmune rheumatic diseases such as rheumatoid arthritis (RA) remains a significant challenge. Often the rheumatologist is restricted to treating and relieving the symptoms and consequences and not the underlying cause of the disease. Oxidative stress occurs in many autoimmune diseases, along with the excess production of reactive oxygen species (ROS) and reactive nitrogen species (RNS).
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- The generation of 3-nitrotyrosine in proteins is a result of oxidative or nitrative stress, potentially serving as a biomarker for inflammatory diseases.
- A new highly sensitive electrochemiluminescence-based ELISA for measuring nitrotyrosine has been developed, offering 50 times greater sensitivity than some existing tests and showing accuracy in quantifying levels in serum samples.
- The ELISA was validated against mass spectrometry, and in a clinical study of surgical patients, it detected a significant increase in nitrotyrosine levels post-surgery, indicating it can effectively measure inflammatory responses.
Significance: Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation of DNA to proteins, lipids, and free amino acids.
Recent Advances: An increased understanding of the biology behind diseases and redox biology has led to more specific and sensitive tools to measure oxidative stress markers, which are very diverse and sometimes very low in abundance.