Publications by authors named "Annie Cudennec"
Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic.
Ronan Depoortère Gihad Dargazanli Genevieve Estenne-Bouhtou Annick Coste Christophe Lanneau Annie Cudennec
Neuropsychopharmacology
November 2005
Article Synopsis
- A new compound called SSR504734 helps increase levels of a chemical called glycine in the brain, which might help with treating symptoms of schizophrenia.
- Schizophrenia-like symptoms can be caused when a specific brain connection (glutamatergic transmission) is impaired, and SSR504734 works by blocking a protein that usually keeps glycine levels low.
- In experiments, SSR504734 showed it could improve brain activity and behaviors in mice and rats that are models for schizophrenia, suggesting it could be a good candidate for treatment.
Article Synopsis
- SSR240612 is a new medicine that blocks a specific receptor in the body called the bradykinin B(1) receptor.
- It was shown to work really well in lab tests, stopping the receptor from causing pain and swelling.
- This medicine might help treat pain and inflammation in different situations, like in mice and rats, showing it could be useful for humans too!
SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]-4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin 1 receptor: II. Neurochemical and behavioral characterization.
Régis Steinberg Richard Alonso Liliane Rouquier Christophe Desvignes Jean-Claude Michaud Annie Cudennec
J Pharmacol Exp Ther
December 2002
SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]-4-piperidinyl)-2-methylpropanamide], a new nonpeptide tachykinin neurokinin 1 (NK1) receptor antagonist, was evaluated against the neurochemical, electrophysiological, and behavioral effects provoked by direct activation of brain tachykinin NK1 receptors or by stress in guinea pigs. SSR240600 (0.1-10 mg/kg i.
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