Publications by authors named "Annick Paquelin"
Article Synopsis
- The study investigates the interactions between the outer membrane heme transporter HasR and the inner membrane protein HasB in Gram-negative bacteria, using advanced molecular dynamics simulations to understand their role in nutrient uptake.
- The simulations reveal important dynamics and protein-protein interactions within the periplasmic space, contributing to the stability and function of the nutrient transport system.
- Experimental validation of the findings indicates that the identified interaction network may also apply to other similar nutrient import systems in Gram-negative bacteria, highlighting its potential significance for antibacterial strategy development.
Hedgehog (Hh) pathway inhibition by the conserved protein Suppressor of Fused (SuFu) is crucial to vertebrate development. By constrast, SuFu loss-of-function mutant has little effect in drosophila. Previous publications showed that the crystal structures of human and drosophila SuFu consist of two ordered domains that are capable of breathing motions upon ligand binding.
View Article and Find Full Text PDFNumerous bacteria are able to use free and haemoprotein-bound haem as iron sources because of the action of small secreted proteins called haemophores. Haemophores have very high affinity for haem, and can therefore extract haem from the haem-carrier proteins and deliver it to the cells by means of specific cell surface receptors. Haem is then taken up and the empty haemophores are recycled.
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