Publications by authors named "Annick Notte"

Understanding the mechanisms responsible for the resistance against chemotherapy-induced cell death is still of great interest since the number of patients with cancer increases and relapse is commonly observed. Indeed, the development of hypoxic regions as well as UPR (unfolded protein response) activation is known to promote cancer cell adaptive responses to the stressful tumor microenvironment and resistance against anticancer therapies. Therefore, the impact of UPR combined to hypoxia on autophagy and apoptosis activation during taxol exposure was investigated in MDA-MB-231 and T47D breast cancer cells.

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Article Synopsis
  • Tumors in low-oxygen (hypoxic) environments alter their metabolism to survive, but the role of mitochondria in this process is not fully understood.
  • Research shows that the hypoxia-inducible factor 1 contributes to mitochondrial hyperfusion and a specific truncation of proteins that leads to increased drug resistance in cancer cells.
  • Silencing the tumor suppressor TP53 reduces this protein truncation and enhances apoptosis, suggesting that TP53 and the protein Mieap play crucial roles in regulating mitochondrial function and cell survival under hypoxic conditions.
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Hypoxia plays an important role in the resistance of tumour cells to chemotherapy. However, the exact mechanisms underlying this process are not well understood. Moreover, according to the cell lines, hypoxia differently influences cell death.

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Since the 1940s, chemotherapy has been the treatment of choice for metastatic disease. Chemotherapeutic agents target proliferating cells, inducing cell death. For most of the history of chemotherapy, apoptosis was thought to be the only mechanism of drug-induced cell death.

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Background: Hypoxia is a hallmark of solid tumors and is associated with metastases, therapeutic resistance and poor patient survival.

Results: In this study, we showed that hypoxia protected MDA-MB-231 breast cancer cells against paclitaxel- but not epirubicin-induced apoptosis. The possible implication of HIF-1 and AP-1 in the hypoxia-induced anti-apoptotic pathway was investigated by the use of specific siRNA.

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