Hepatic and Renal Toxicity Induced by TiO Nanoparticles in Rats: A Morphological and Metabonomic Study.

Titanium dioxide (TiO) nanoparticles (NPs) are produced abundantly and are frequently used as a white pigment in the manufacture of paints, foods, paper, and toothpaste. Despite the wide ranges of uses, there is a lack of information on the impact of NPs on animal and human health. In the present study, rats were exposed to different doses of TiO nanoparticles and sacrificed, respectively, 4 days, 1 month, and 2 months after treatment.

Morphological alterations induced by the exposure to TiO nanoparticles in primary cortical neuron cultures and in the brain of rats.

Nowadays, nanoparticles (NPs) of titanium dioxide (TiO) are abundantly produced. TiO NPs are present in various food products, in paints, cosmetics, sunscreens and toothpastes. However, the toxicity of TiO NPs on the central nervous system has been poorly investigated until now.